From: Sohn, Winnie <w...@amgen.com> Sent: Monday, May 14, 2018 8:41 PM To: Nick Holford <n.holf...@auckland.ac.nz> Subject: RE: Using Root-finding techniques to find Cmax/Tmax
Hi Nick, I have tried to unsubscribe multiple times to NMusers. Can you please help? Thanks, Winnie From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> <owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com>> On Behalf Of Nick Holford Sent: Monday, May 14, 2018 11:30 AM To: Bauer, Robert <robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com>>; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: [external] [NMusers] RE: Using Root-finding techniques to find Cmax/Tmax Bob, Thanks for the zip file. And for the motivation to explore intro7.pdf – always something interesting to learn in the modelling world (unlike those stuck in the NCA doldrums). Nick From: Bauer, Robert <robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com>> Sent: Monday, May 14, 2018 7:16 PM To: Nick Holford <n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac.nz>>; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: RE: Using Root-finding techniques to find Cmax/Tmax Nick: A cmax_root_finder.zip file is now supplied. nonmem_reserved_general is not intended to be humanly read, but used in the control stream for easy access of reserved variables. A copy is also in ..\util of your NONMEM installation. Use of it is described in ..\guides\intro7.pdf Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 robert.ba...@iconplc.com<mailto:robert.ba...@iconplc.com> www.iconplc.com<https://urldefense.proofpoint.com/v2/url?u=http-3A__www.iconplc.com_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=59XSQi0f1WJqQwbCSm4TIyGoFCN5a2fZp6h-rPTTEIo&e=> From: Nick Holford [mailto:n.holf...@auckland.ac.nz] Sent: Monday, May 14, 2018 9:54 AM To: Bauer, Robert; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: RE: Using Root-finding techniques to find Cmax/Tmax Hi Bob, Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge – I could barely understand a line of it. Any chance you could zip up all the files into one archive file? I find myself faced with downloading a couple of pages of files one file at a time. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: n.holf...@auckland.ac.nz<mailto:n.holf...@auckland.ac.nz> http://holford.fmhs.auckland.ac.nz/<https://urldefense.proofpoint.com/v2/url?u=http-3A__holford.fmhs.auckland.ac.nz_&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=xzhta86tu9zqgjD6ar_OCJVv6dvFX2Iv5EAQVyrjBRU&e=> http://orcid.org/0000-0002-4031-2514<https://urldefense.proofpoint.com/v2/url?u=http-3A__orcid.org_0000-2D0002-2D4031-2D2514&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=-1wbg-UMN49IO3o0BXMMs6UAHYIxfY_CoXdjlQ3_zTo&e=> Read the question, answer the question, attempt all questions From: owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com> <owner-nmus...@globomaxnm.com<mailto:owner-nmus...@globomaxnm.com>> On Behalf Of Bauer, Robert Sent: Monday, May 14, 2018 5:55 PM To: nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax Dear nmusers: Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in https://nonmem.iconplc.com/nonmem/cmax_root_finder<https://urldefense.proofpoint.com/v2/url?u=https-3A__nonmem.iconplc.com_nonmem_cmax-5Froot-5Ffinder&d=DwMGaQ&c=Sexio4usKrYWFsrnxgjbcQ&r=bEsdLDPPBcfBBjb3EGSiEQ&m=F-bYLztv3ZJR19FV46iusHnc0PwOsEM5kSmJ34wrEKI&s=j8gIhRuX6BEDI20rEvlAkqTz4VdJca56C0s5cTyNCYY&e=> Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. 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