[NMusers] RE: 0PRED EXIT CODE = 1

[Marie Rajerison]

Dear Sebastien,

Here is my $ERROR block :

$ERROR
IPRED=F
RUV_P=F*THETA(7)
;RUV_A=THETA(8)
SD=SQRT(RUV_P*RUV_P)
Y=F+ERR(1)*SD
IRES=DV-IPRED
IWRES=IRES/SD

Thank you for your help

Marie

De : Sébastien Bihorel 
Envoyé : mercredi 18 septembre 2024 14:10
À : Marie Rajerison ; nmusers@globomaxnm.com
Objet : Re: 0PRED EXIT CODE = 1

Hi Marie,

Can you please share your $ERROR block?

Thanks

From: owner-nmus...@globomaxnm.com 
mailto:owner-nmus...@globomaxnm.com>> on behalf 
of Marie Rajerison 
mailto:marie.rajeri...@corteriapharma.com>>
Sent: Wednesday, September 18, 2024 5:22 AM
To: nmusers@globomaxnm.com 
mailto:nmusers@globomaxnm.com>>
Subject: [External] [NMusers] 0PRED EXIT CODE = 1

Dear NM users, I have often noticed the following error message on NM chat but 
I have never really found a concrete solution to resolve it. I might have 
missed it. Can anyone advise how to fix this error? 0PRED EXIT CODE = 1 
0INDIVIDUAL NO. 

Dear NM users,



I have often noticed the following error message on NM chat but I have never 
really found a concrete solution to resolve it. I might have missed it.

Can anyone advise how to fix this error?



0PRED EXIT CODE = 1

0INDIVIDUAL NO.   4   ID= 4.00E+00   (WITHIN-INDIVIDUAL) DATA 
REC NO.   2

THETA=

  1.00E-03   5.00E-01   1.00E+01   1.00E+01   1.00E-01   1.00E+01   1.00E+00

OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0

F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).

 Elapsed estimation time in seconds: 0.00



Thank you in advance for your help



Marie





Marie RAJERISON

PharmD PhD

Pharmacometrician

e-mail: 
marie.rajeri...@corteriapharma.com

128 rue de la Boetie

75008 Paris

France

[cid:image001.jpg@01DB0B6E.D55F9200]



This e-mail and any attachment hereto, is intended only for use by the 
addressee(s) named above and may contain legally privileged and/or confidential 
information. If you are not the intended recipient of this e-mail, any 
dissemination, distribution or copying of this email, or any attachment hereto, 
is strictly prohibited. If you receive this email in error please immediately 
notify me by return electronic mail and permanently delete this email and any 
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printout thereof. Finally, please note that only authorized representatives of 
Regeneron Pharmaceuticals, Inc. have the power and authority to enter into 
business dealings with any third party.

Re: [NMusers] Re: 0PRED EXIT CODE = 1

[Leonid Gibiansky]

This is a generic error message, nothing informative except indicates 
that there are some numerical problems.


You can try to change ADVAN (6 to 13, if this is differential equations 
model) or TOL on $SUBR record,  SIGL and NSIG on $EST, change initial 
conditions to the values of the previous model (assuming that there was 
some model) or to a realistic range. Sometimes MCETA=1000 on $EST recods 
helps with this message. Often this is related to the outliers, so it 
helps to clean the data. One can try to increase initial values of 
$SIGMAs or add random effect on the residual error.


If this is a complex model, you may try to start with something simple, 
like linear, and use the output as initial parameters, and also look for 
outliers (very large CWRES).


Thank you
Leonid



On 9/18/2024 8:09 AM, Sébastien Bihorel wrote:

Hi Marie,

Can you please share your $ERROR block?

Thanks

*From:* owner-nmus...@globomaxnm.com  on 
behalf of Marie Rajerison 

*Sent:* Wednesday, September 18, 2024 5:22 AM
*To:* nmusers@globomaxnm.com 
*Subject:* [External] [NMusers] 0PRED EXIT CODE = 1
Dear NM users, I have often noticed the following error message on NM 
chat but I have never really found a concrete solution to resolve it. I 
might have missed it. Can anyone advise how to fix this error? 0PRED 
EXIT CODE = 1 0INDIVIDUAL NO. 


Dear NM users,

I have often noticed the following error message on NM chat but I have 
never really found a concrete solution to resolve it. I might have 
missed it.


Can anyone advise how to fix this error?

0PRED EXIT CODE = 1

0INDIVIDUAL NO.   4   ID= 4.00E+00   (WITHIN-INDIVIDUAL) 
DATA REC NO.   2


THETA=

   1.00E-03   5.00E-01   1.00E+01   1.00E+01   1.00E-01   1.00E+01   
1.00E+00


OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0

F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).

  Elapsed estimation time in seconds: 0.00

Thank you in advance for your help

Marie

*Marie RAJERISON*

*PharmD PhD*

*Pharmacometrician*

*e-mail: marie.rajeri...@corteriapharma.com 
*


128 rue de la Boetie

75008 Paris

France


This e-mail and any attachment hereto, is intended only for use by the 
addressee(s) named above and may contain legally privileged and/or 
confidential information. If you are not the intended recipient of this 
e-mail, any dissemination, distribution or copying of this email, or any 
attachment hereto, is strictly prohibited. If you receive this email in 
error please immediately notify me by return electronic mail and 
permanently delete this email and any attachment hereto, any copy of 
this e-mail and of any such attachment, and any printout thereof. 
Finally, please note that only authorized representatives of Regeneron 
Pharmaceuticals, Inc. have the power and authority to enter into 
business dealings with any third party.

[NMusers] Re: 0PRED EXIT CODE = 1

[Sébastien Bihorel]

Hi Marie,

Can you please share your $ERROR block?

Thanks

From: owner-nmus...@globomaxnm.com  on behalf of 
Marie Rajerison 
Sent: Wednesday, September 18, 2024 5:22 AM
To: nmusers@globomaxnm.com 
Subject: [External] [NMusers] 0PRED EXIT CODE = 1

Dear NM users, I have often noticed the following error message on NM chat but 
I have never really found a concrete solution to resolve it. I might have 
missed it. Can anyone advise how to fix this error? 0PRED EXIT CODE = 1 
0INDIVIDUAL NO. 


Dear NM users,



I have often noticed the following error message on NM chat but I have never 
really found a concrete solution to resolve it. I might have missed it.

Can anyone advise how to fix this error?



0PRED EXIT CODE = 1

0INDIVIDUAL NO.   4   ID= 4.00E+00   (WITHIN-INDIVIDUAL) DATA 
REC NO.   2

THETA=

  1.00E-03   5.00E-01   1.00E+01   1.00E+01   1.00E-01   1.00E+01   1.00E+00

OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0

F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).

 Elapsed estimation time in seconds: 0.00



Thank you in advance for your help



Marie





Marie RAJERISON

PharmD PhD

Pharmacometrician

e-mail: 
marie.rajeri...@corteriapharma.com

128 rue de la Boetie

75008 Paris

France

[cid:image001.jpg@01DB09BC.93338390]


 
This e-mail and any attachment hereto, is intended only for use by the 
addressee(s) named above and may contain legally privileged and/or confidential 
information. If you are not the intended recipient of this e-mail, any 
dissemination, distribution or copying of this email, or any attachment hereto, 
is strictly prohibited. If you receive this email in error please immediately 
notify me by return electronic mail and permanently delete this email and any 
attachment hereto, any copy of this e-mail and of any such attachment, and any 
printout thereof. Finally, please note that only authorized representatives of 
Regeneron Pharmaceuticals, Inc. have the power and authority to enter into 
business dealings with any third party.