I have a question regarding significance testing for the difference in the
ratio of means.
The data consists of a control and a test group, each with and without
treatment. I am interested in testing if the treatment has a significantly
different effect (say, in terms of fold-activation) on the
Sigh...
(Again!) These are primarily statistical, not R, issues. I would urge
that you seek local statistical help. You appear to be approaching
this with a good deal of semi-informed adhoc-ery. Standard methodology
should be applicable, but it would be presumptuous and ill-advised of
me to
My apologies if my request is off topic and for my admittedly
half-baked understanding of the topic. I'm afraid trying to talk with
the local statistical help, and trying to post on several general
statistical forums to look for proper guidance has not yielded any
response much less any helpful
The fact that your currents are apparently intrinsically positive and
the variance increases with current plus the fact that you are
interested in ratio statistics suggests that your data would benefit
from an initial log transform of the data. All of your issues would
then disappear, given
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