Re: [R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-03-02 Thread Erich Studerus
Thanks, this comes close to what I need, but the problem is that I have repeated measures in each comparison and SimComp does not seem to handle this. In my experiments, each subject received both placebo and the drug in a randomized order. So, I want to do multiple paired t-test corrected for

Re: [R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-03-01 Thread Erich Studerus, Psychiatrische Uni-Klinik
Johannes Huesing johan...@huesing.name wrote: Couldn't you re-phrase your model by including timepoint as a continuous regressor and scale as a factor? Well, the measuring time points are 70 170, 300 and 1440 minutes after drug intake. Since the influence of time is cerainly not linear, I

Re: [R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-03-01 Thread Mark Difford
Hi Erich, Look at the SimComp package, which handles multiple endpoints, i.e. columns of response variables. Ratio-comparisons are also handled. Good ready-made range of comparisons; you can also set up your own. Regards, Mark. Erich Studerus wrote: Johannes Huesing johan...@huesing.name

Re: [R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-02-28 Thread Erich Studerus, Psychiatrische Uni-Klinik
Thanks, but as far as I know the multcomp package and the tukeyHSD function can only handle one dependent variable, whereas I have 60 dependent variables. Regards, Erich On Sat, 28 Feb 2009 17:41:11 + (UTC) Dieter Menne dieter.me...@menne-biomed.de wrote: Erich Studerus erich.studerus

Re: [R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-02-28 Thread Johannes Huesing
Erich Studerus, Psychiatrische Uni-Klinik erich.stude...@bli.uzh.ch [Sat, Feb 28, 2009 at 09:23:05PM CET]: Thanks, but as far as I know the multcomp package and the tukeyHSD function can only handle one dependent variable, whereas I have 60 dependent variables. Couldn't you re-phrase your

[R] Adjusting confidence intervals for paired t-tests of multiple endpoints

2009-02-27 Thread Erich Studerus
Dear R-users, In a randomized placebo-controlled within-subject design, subjects recieved a psycho-active drug and placebo. Subjects filled out a questionnaire containing 15 scales on four different time points after drug administration. In order to detect drug effects on each time point, I