Re: [Samtools-help] REF_CACHE

2018-02-08 Thread James Bonfield
On Thu, Feb 08, 2018 at 09:32:00AM -0700, Brent Pedersen wrote:
> I've been working more with crams lately and in some cases, it seems
> the default behavior of htslib is to automatically start downloading
> reference files locally even though I have not set REF_CACHE or
> REF_PATH. This is deep in a complex pipeline behind several layers of
> abstraction, but I think this is the default.

If you don't set them it'll automatically default to using the EBI for
REF_PATH and ~/.cache/hts-seqs (IIRC) for REF_CACHE.

If you really wish to totally disable them, keep REF_CACHE clear and
set REF_PATH to somewhere with no files, eg /foo, and it'll fail the
search.

It should then fail.

James

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James Bonfield (j...@sanger.ac.uk)
The Sanger Institute, Hinxton, Cambs, CB10 1SA


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[Samtools-help] REF_CACHE

2018-02-08 Thread Brent Pedersen
Hi,
I've been working more with crams lately and in some cases, it seems
the default behavior of htslib is to automatically start downloading
reference files locally even though I have not set REF_CACHE or
REF_PATH. This is deep in a complex pipeline behind several layers of
abstraction, but I think this is the default.

Is there a way to have htslib error if the fasta is not specified
instead of defaulting to download?

thanks,
-Brent

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