Biologically synthesised silver nanoparticles from three diverse family
of plant extracts and their anticancer activity against epidermoid A431
car... - PubMed - NCBI, http://www.ncbi.nlm.nih.gov/pubmed/26196716
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J Colloid Interface Sci. <#> 2015 Nov 1;457:329-38. doi:
10.1016/j.jcis.2015.07.012. Epub 2015 Jul 7.
Biologically synthesised silver nanoparticles from three diverse
family of plant extracts and their anticancer activity against
epidermoid A431 carcinoma.
Nayak D
</pubmed/?term=Nayak%20D%5BAuthor%5D&cauthor=true&cauthor_uid=26196716>^1 ,
Pradhan S
</pubmed/?term=Pradhan%20S%5BAuthor%5D&cauthor=true&cauthor_uid=26196716>^1
, Ashe S
</pubmed/?term=Ashe%20S%5BAuthor%5D&cauthor=true&cauthor_uid=26196716>^1
, Rauta PR
</pubmed/?term=Rauta%20PR%5BAuthor%5D&cauthor=true&cauthor_uid=26196716>^1
, Nayak B
</pubmed/?term=Nayak%20B%5BAuthor%5D&cauthor=true&cauthor_uid=26196716>^2 .
Author information<#>
* ^1 Immunology and Molecular Medicine Laboratory, Department of Life
Science, National Institute of Technology, Rourkela, Odisha 769008,
India.
* ^2 Immunology and Molecular Medicine Laboratory, Department of Life
Science, National Institute of Technology, Rourkela, Odisha 769008,
India. Electronic address: nay...@nitrkl.ac.in.
Abstract
HYPOTHESIS:
Biological synthesis of silver nanoparticles is a cost effective natural
process where the phytochemicals specifically phenols, flavonoids and
terpenoids present in the plant extracts act as capping and reducing
agent. Due to their nano size regime the silver nanoparticles may
directly bind to the DNA of the pathogenic bacterial strains leading to
higher antimicrobial activity.
EXPERIMENT:
In the current study silver nanoparticles were synthesised using plant
extracts from different origin Cucurbita maxima (petals), Moringa
oleifera (leaves) and Acorus calamus (rhizome). The synthesised
nanoparticles were characterized by UV-visible spectroscopy, dynamic
light scattering (DLS), X-ray diffraction (XRD), field emission scanning
electron microscopy (Fe-SEM) and Fourier transform infrared spectroscopy
(FTIR).
FINDING:
Highly crystalline, roughly spherical and cuboidal silver nanoparticles
of 30-70nm in size were synthesised. The nanoparticles provided strong
antimicrobial activity against pathogenic strains. The effect of the
synthesised nanoparticles against A431 skin cancer cell line was tested
for their toxicity by
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) dye.
The IC50 values of 82.39±3.1, 83.57±3.9 and 78.58±2.7μg/ml were
calculated for silver nanoparticles synthesised by C. maxima, M.
oleifera and A. calamus respectively.
Copyright © 2015 Elsevier Inc. All rights reserved.
KEYWORDS:
Anticancer activity; Antimicrobial activity; Dynamic light scattering;
FTIR; Fe-SEM; Green synthesis; Phytochemical; Silver nanoparticles; Skin
cancer; Zeta potential
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