Your kernel log shows it is having trouble with the mouse. This might be
a fault with the mouse or the USB port. It might also be a kernel bug,
but that's less likely...

[  551.252894] usb 1-6: reset low-speed USB device number 3 using xhci_hcd
[  551.520701] usb 1-6: device descriptor read/64, error -71
[  556.957250] usb 1-6: reset low-speed USB device number 3 using xhci_hcd
[  557.733478] usb 1-6: USB disconnect, device number 3
[  558.061164] usb 1-6: new low-speed USB device number 4 using xhci_hcd
[  558.212826] usb 1-6: New USB device found, idVendor=046d, idProduct=c05a
[  558.212832] usb 1-6: New USB device strings: Mfr=1, Product=2, SerialNumber=0
[  558.212837] usb 1-6: Product: USB Optical Mouse
[  558.212841] usb 1-6: Manufacturer: Logitech
[  558.215745] input: Logitech USB Optical Mouse as 
/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.0/0003:046D:C05A.0005/input/input15
[  558.216101] hid-generic 0003:046D:C05A.0005: input,hidraw3: USB HID v1.11 
Mouse [Logitech USB Optical Mouse] on usb-0000:00:14.0-6/input0
[  687.645465] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[  777.148862] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[  777.417072] usb 1-6: Device not responding to setup address.
[  777.625107] usb 1-6: Device not responding to setup address.
[  777.832620] usb 1-6: device not accepting address 4, error -71
[  778.100621] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[ 1095.999728] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[ 1096.267472] usb 1-6: device descriptor read/64, error -71
[ 1096.643504] usb 1-6: device descriptor read/64, error -71
[ 1097.019526] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[ 1097.287539] usb 1-6: device descriptor read/64, error -71
[ 1097.663495] usb 1-6: device descriptor read/64, error -71
[ 1098.039490] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[ 1098.039923] usb 1-6: Device not responding to setup address.
[ 1098.247947] usb 1-6: Device not responding to setup address.
[ 1098.455509] usb 1-6: device not accepting address 4, error -71
[ 1098.723506] usb 1-6: reset low-speed USB device number 4 using xhci_hcd
[ 1098.723945] usb 1-6: Device not responding to setup address.
[ 1098.931938] usb 1-6: Device not responding to setup address.
[ 1099.139470] usb 1-6: device not accepting address 4, error -71
[ 1099.139617] usb 1-6: USB disconnect, device number 4
[ 1099.327521] usb 1-6: new low-speed USB device number 5 using xhci_hcd
[ 1099.455500] usb 1-6: device descriptor read/64, error -71
[ 1099.691465] usb 1-6: device descriptor read/64, error -71
[ 1099.927528] usb 1-6: new low-speed USB device number 6 using xhci_hcd
[ 1100.055542] usb 1-6: device descriptor read/64, error -71
[ 1100.291539] usb 1-6: device descriptor read/64, error -71
[ 1100.399599] usb usb1-port6: attempt power cycle
[ 1101.055512] usb 1-6: new low-speed USB device number 7 using xhci_hcd
[ 1101.055908] usb 1-6: Device not responding to setup address.
[ 1101.263962] usb 1-6: Device not responding to setup address.
[ 1101.471513] usb 1-6: device not accepting address 7, error -71
[ 1101.599512] usb 1-6: new low-speed USB device number 8 using xhci_hcd
[ 1101.599924] usb 1-6: Device not responding to setup address.
[ 1101.807962] usb 1-6: Device not responding to setup address.
[ 1102.015541] usb 1-6: device not accepting address 8, error -71
[ 1102.015632] usb usb1-port6: unable to enumerate USB device
[ 1143.931796] usb 1-6: new low-speed USB device number 9 using xhci_hcd
[ 1144.083477] usb 1-6: New USB device found, idVendor=046d, idProduct=c05a
[ 1144.083483] usb 1-6: New USB device strings: Mfr=1, Product=2, SerialNumber=0
[ 1144.083487] usb 1-6: Product: USB Optical Mouse

** Package changed: xorg (Ubuntu) => linux (Ubuntu)

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https://bugs.launchpad.net/bugs/1834578

Title:
  Mouse stop working

Status in linux package in Ubuntu:
  Confirmed

Bug description:
  USB mouse stop working randomly

  ProblemType: Bug
  DistroRelease: Ubuntu 18.04
  Package: xorg 1:7.7+19ubuntu7.1
  ProcVersionSignature: Ubuntu 4.15.0-53.57-generic 4.15.18
  Uname: Linux 4.15.0-53-generic x86_64
  NonfreeKernelModules: nvidia_modeset nvidia
  .proc.driver.nvidia.gpus.0000.01.00.0: Error: [Errno 21] Is a directory: 
'/proc/driver/nvidia/gpus/0000:01:00.0'
  .proc.driver.nvidia.registry: Binary: ""
  .proc.driver.nvidia.version:
   NVRM version: NVIDIA UNIX x86_64 Kernel Module  390.116  Sun Jan 27 07:21:36 
PST 2019
   GCC version:  gcc version 7.4.0 (Ubuntu 7.4.0-1ubuntu1~18.04.1)
  ApportVersion: 2.20.9-0ubuntu7.6
  Architecture: amd64
  BootLog: Error: [Errno 13] Permission denied: '/var/log/boot.log'
  CompositorRunning: None
  CurrentDesktop: ubuntu:GNOME
  Date: Fri Jun 28 10:24:54 2019
  DistUpgraded: Fresh install
  DistroCodename: bionic
  DistroVariant: ubuntu
  DkmsStatus:
   nvidia, 390.116, 4.15.0-52-generic, x86_64: installed
   nvidia, 390.116, 4.15.0-53-generic, x86_64: installed
   virtualbox, 5.2.18, 4.15.0-52-generic, x86_64: installed
   virtualbox, 5.2.18, 4.15.0-53-generic, x86_64: installed
  GraphicsCard:
   NVIDIA Corporation GP107 [GeForce GTX 1050 Ti] [10de:1c82] (rev a1) (prog-if 
00 [VGA controller])
     Subsystem: ASUSTeK Computer Inc. GP107 [GeForce GTX 1050 Ti] [1043:85d3]
  InstallationDate: Installed on 2018-09-21 (280 days ago)
  InstallationMedia: Ubuntu 18.04.1 LTS "Bionic Beaver" - Release amd64 
(20180725)
  Lsusb:
   Bus 002 Device 001: ID 1d6b:0003 Linux Foundation 3.0 root hub
   Bus 001 Device 009: ID 046d:c05a Logitech, Inc. M90/M100 Optical Mouse
   Bus 001 Device 002: ID 0518:5111 EzKEY Corp. 
   Bus 001 Device 001: ID 1d6b:0002 Linux Foundation 2.0 root hub
  MachineType: System manufacturer System Product Name
  ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-4.15.0-53-generic 
root=UUID=8e5738ba-3515-4603-abfb-a837482ef7ba ro quiet splash vt.handoff=1
  SourcePackage: xorg
  UpgradeStatus: No upgrade log present (probably fresh install)
  dmi.bios.date: 07/07/2017
  dmi.bios.vendor: American Megatrends Inc.
  dmi.bios.version: 0809
  dmi.board.asset.tag: Default string
  dmi.board.name: PRIME B250M-K
  dmi.board.vendor: ASUSTeK COMPUTER INC.
  dmi.board.version: Rev X.0x
  dmi.chassis.asset.tag: Default string
  dmi.chassis.type: 3
  dmi.chassis.vendor: Default string
  dmi.chassis.version: Default string
  dmi.modalias: 
dmi:bvnAmericanMegatrendsInc.:bvr0809:bd07/07/2017:svnSystemmanufacturer:pnSystemProductName:pvrSystemVersion:rvnASUSTeKCOMPUTERINC.:rnPRIMEB250M-K:rvrRevX.0x:cvnDefaultstring:ct3:cvrDefaultstring:
  dmi.product.family: To be filled by O.E.M.
  dmi.product.name: System Product Name
  dmi.product.version: System Version
  dmi.sys.vendor: System manufacturer
  version.compiz: compiz N/A
  version.libdrm2: libdrm2 2.4.97-1ubuntu1~18.04.1
  version.libgl1-mesa-dri: libgl1-mesa-dri 19.0.2-1ubuntu1.1~18.04.1
  version.libgl1-mesa-glx: libgl1-mesa-glx 19.0.2-1ubuntu1.1~18.04.1
  version.nvidia-graphics-drivers: nvidia-graphics-drivers-* N/A
  version.xserver-xorg-core: xserver-xorg-core 2:1.19.6-1ubuntu4.3
  version.xserver-xorg-input-evdev: xserver-xorg-input-evdev N/A
  version.xserver-xorg-video-ati: xserver-xorg-video-ati 1:18.0.1-1
  version.xserver-xorg-video-intel: xserver-xorg-video-intel 
2:2.99.917+git20171229-1
  version.xserver-xorg-video-nouveau: xserver-xorg-video-nouveau 1:1.0.15-2

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