Nearly all clients are on the Streaming API successfully. There is one notable exception: clients that perform a large HTTP POST operation with the follow= or track= parameter. At some threshold size, requests are not making it into the Hosebird process. We're working on fixing this remaining Streaming API issue.
Changes have been made in the networking infrastructure and not every last piece of Twitter functionality can, as of yet, be supported reliably. We will get there, but this is not a trivial task. At this traffic volume, visibility into the interactions between the following interdependent dimensions is difficult: networking gear, the servers, the webservers, the application containers, rate limiting logic, browsers, api clients, valid traffic, invalid traffic, well-formed traffic, and ill-formed traffic. Multiply the cardinality of these dimensions and you've quite a cross-product. Then, there's an attack dynamically probing and leveraging weaknesses. We understand the impact this is having on the community. Thanks for your understanding. John Kalucki http://twitter.com/jkalucki Services, Twitter inc.