Dear Drs. Nuttall and Hess,


Being one of many outcomes researchers to have undertaken to identify sepsis 
and severe sepsis retrospectively using administrative hospital data, may I 
humbly recommend a review of a paper we published in Advances in Sepsis in 
2005? Our attempt to improve identification of patients retrospectively took 
place as uptake of ICD-9-CM codes 995.9x was expanding but not yet in full 
force. Just as now, the coding of sepsis and severe sepsis using the newer 
ICD-9-CM codes was more often found as non-primary codes.



For our study, we began with the method suggested earlier by Dr. Angus and 
colleagues and then presented the results of using certain methodological 
options to improve identification when one had additional data elements at 
hand, such as evidence of support for organ dysfunction like use of 
vasopressors, mechanical ventilation, renal replacement therapy, and can 
identify the timing of these interventions within the hospital stay. I offer 
the following reference in case it prompts others to develop better, more 
currently relevant methods: Challenges of Identification of Severe Sepsis in 
Administrative Data and Feasibility of an Alternative Method. Adv Sepsis 2005; 
5(1): 11-18. (http://www.advancesinsepsis.com/details.aspx?itemid=4163 ).

I would be interested in your impressions of our prior feasibility study and 
your suggestions for currently relevant improvements.

Best regards,

Frank R. Ernst, PharmD, MS
Principal, Premier Research Services
Premier healthcare alliance, Charlotte, NC 28277
704.816.5092 tel / fax  ::  [email protected] 
<mailto:[email protected]>

From: [email protected] 
[mailto:[email protected]] On Behalf Of Stuart Nuttall
Sent: Thursday, April 12, 2012 4:07 PM
To: Hess, Dr. Donald
Cc: '[email protected]'
Subject: Re: [Sepsis Groups] Sepsis & severe sepsis: A primary or secondary 
diagnosis?

Hi Dr Hess,

I would certainly agree although appreciate there may be UK/US differences

I've been involved in conducting the College of Emergency Medicine Sepsis Audit 
for our ED this spring.  Trying to identify the patients retrospectively 
through coding (either hospital or ED coding systems) failed to generate any 
meaningful data.

In my opinion, given the current coding systems in use, prospective 
identification of these patients using a screening tool in the ED may be more 
reliable. This is then retained when the patient leaves the ED.  These patients 
can then be audited.  I'm aware that for this method patients will still slip 
though the net and the diagnosis may become more apparent once they have hit 
the ward but it does seem to be an improvement on just using coding.

I think I remember someone mentioning on this list last year that they chase up 
all patients through the ED (possibly hospital) who had blood cultures or 
raised WCC's to try and ensure capture of as many patients as possible - more 
thorough but more time consuming I guess.  Would be interested to hear what 
other departments do.

Regards

Dr Stuart Nuttall
Consultant in Emergency Medicine Leeds Teaching Hospitals.

On 12 Apr 2012, at 13:09, Hess, Dr. Donald wrote:


After reading a recent article in the April 4, 2012 issue of JAMA (Lindauer PK, 
et al, Association of Diagnostic Coding With Trends in Hospitalizations and 
Mortality of Patients With Pneumonia, 2003-2009 -  
http://jama.ama-assn.org/content/307/13/1405.full), I decided to look at my 
institution's administrative data regarding the number of hospitalizations in 
the past 4 years that were coded with the ICD9# for either sepsis or severe 
sepsis as the primary diagnosis. There were none. Zero.  I have long suspected 
that one obstacle to diagnosing sepsis or severe sepsis is that most physicians 
(and perhaps coders, too) regard it as a secondary diagnosis. That sepsis is 
always secondary to something else...not a primary diagnosis that represents a 
final common pathway due to a number of different causes. There are likely a 
number of other cognitive factors related to the avoidance of diagnosing sepsis 
and severe sepsis as a primary diagnosis. But evidently physicians & coders at 
other institutions are doing it. I look forward to your comments.

Regards,

Dr. Don Hess

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