When I have a patient with a low SCVO2 - I Look at a variety of items.  I  like 
to start with first the oxygen consumption side - What are her demands that I 
can help with - basic things like - fever, anxiety, pain, shivering and muscle 
activity - I try to take care of this and treat this first.

Secondly I look at oxygenation - is that adequate?  Do we need to increase her 
Fi02 - is she ventilating appropriately?  Then I look at her HGB Is she 
bleeding - is she anemic?  Do we need to transfuse??

Third, I look at Cardiac output - whats the HR and do I need to treat ?  Then 
what is my pre-load, afterload and contractility status to make sure I am 
giving the appropriate product to the patient whether that be a positive 
inotrope, vasopressor or fluids.

Just my way of looking at all the items that affect SCVO2.  Hope this is 
helpful!!

Angela Craig APN,MS,CCNS
Clinical Nurse Specialist
Intensive Care Unit
Cookeville Regional Medical Center
931-783-5035
________________________________
From: [email protected] 
[mailto:[email protected]] On Behalf Of 
Sparling-Broccolo, Erin ARMC-SICU
Sent: Wednesday, December 19, 2012 11:16 AM
To: [email protected]
Cc: Houston, Katrina ARMC-Performance Improvement
Subject: Re: [Sepsis Groups] Maternal sepsis with low scvo2

     While not an expert, and my realm of experience is generally not in the 
Maternal-Child realm, I can offer the following thoughts...The key thing is her 
lactate.  If her lactate is normalizing that indicates that oxygenation demands 
are being met on a cellular level, and even though the extraction is elevated, 
supply is meeting current demand with anaerobic metabolism resolved (creating 
and delivering another human being, healing  and dealing with sepsis is hard 
work!!).
     The arguably empiric administration of PRBCs with normalizing lactate and 
clinical improvement carries risk that may outweigh the benefits.  The big 
picture should be examined for patient specific factors that would tilt one in 
favor of transfusion - is she currently on supplemental 02?  What is her 
activity level?  Is she on bed rest or ambulating?  Is she able to tolerate the 
increased activity required for discharge and to prevent other complications 
such as VTE?   Is she currently on Iron supplementation and stool softener?   
Why is her hgb 8.2?  What was her CBC baseline - both count and morphology? I 
did not see mention of whether there was significant bleeding during the C 
section that accounts for this level, but can it be adequately explained?  Any 
splenomegaly?  I see that you mention that she did have thrombocytopenia but it 
is resolving.  I am sure you have considered iatrogenic causes such as HIT or 
common pharmacologic culprits  in the differential.   You don't mention 
morphology so I am guessing there is no issue there.


Erin Sparling Broccolo  MSN-Ed RN CCRN
Critical Care Clinical Nurse Educator
Arrowhead Regional Medical Center
Colton, CA
[email protected]<mailto:[email protected]>
909-580-2556

                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                   .

From: Houston, Katrina ARMC-Performance Improvement
Sent: Wednesday, December 19, 2012 8:08 AM
To: Fletcher, Annabelle ARMC-Performance Improvement; Sparling-Broccolo, Erin 
ARMC-SICU
Subject: FW: [Sepsis Groups] Maternal sepsis with low scvo2

Hmmm! Wish we could help...

From: 
[email protected]<mailto:[email protected]>
 [mailto:[email protected]] On Behalf Of Dr.Sunil T 
Pandya
Sent: Tuesday, December 18, 2012 6:55 PM
To: 
[email protected]<mailto:[email protected]>
Subject: [Sepsis Groups] Maternal sepsis with low scvo2

Hi friends,

We have a young lady who had premature rupture of membranes (PROM), had an 
emergency Cesarean section after 48Hrs, was already on prophylactic antibiotics 
(IV. Cephazolin) as per the protocol.

Intraoperatively developed refractory hypotension / full blown SIRS 
(Unexplained by low dose spinal), and chorio amnionitis - severe sepsis was 
suspected / and confirmed  (High vag swab at admission revealed Klebsiella 
growth) considering 48 hrs of PROM. Sepsis profile / CVP line inserted for 
fluid administration and vasopressors support. Lactate was 4 and SCVO2 was 48%. 
(Hb-10g).

Change of antibiotics as per the cultures and fluids and nor adr / organ 
supports etc. have helped her and is stabilizing.

Her lactate improved and is within normal limits. SCVO2 is still @ 55% and her 
Hb is 8.2g%. CLinically she is doing good and on soft diet. Blood culture also 
was positive for klebsiella

My question to the the expert is:

My fellows were debating whether to give her couple of units of Packed cell 
transfusion in view of low ScVO2.....I seek you opinion as well - Does she need 
blood transfusion?

She has come out of all organ dysfunctions (Renal / ALI / Low plt) and is 
asymptomatic and white cell counts are 10800/cumm, Polymorphs - 72%, Bands - 4%!

Thanking you in advance!

Regards,
Sunil

------------

Dr.Sunil T Pandya

Hon. Secretary, Association of Obstetric Anaesthesiologists, India 
(www.aoaindia.com<http://www.aoaindia.com>)
Hon. Secretary, Society of Obstetric Medicine, India

Head, Dept. of Anaesthesia, Pain and Critical Care,
Fernandez Hospital (Health care for Women and the Newborn), 
www.fernandezhospital.com<http://www.fernandezhospital.com>

Director, Prerna Anaesthesia and Critical Care Services Pvt Ltd 
(www.prernaanaesthesia.com<http://www.prernaanaesthesia.com>)
Hyderabad, India.

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