I was wondering if anyone could provide recommendations on best practices for initial antibiotic dosing in sepsis. We have always been aggressive upfront with antibiotics but our antibiotics stewardship team is appropriately questioning if we should continue this practice. Should we use a "one-dose-fit-all approach" for everyone or should we dose adjust based on organ dysfunction, drug toxicity, drug pk/pd, fluid status, etc. The one dose approach did help with timeliness of antibiotic administration since we could stock medications in Pyxis. Any suggestions welcome Thanks Fiona
________________________________________ From: Sepsisgroups <[email protected]> on behalf of [email protected] <[email protected]> Sent: Friday, July 31, 2015 2:14:08 PM To: [email protected] Subject: Sepsisgroups Digest, Vol 165, Issue 4 Send Sepsisgroups mailing list submissions to [email protected] To subscribe or unsubscribe via the World Wide Web, visit http://lists.sepsisgroups.org/listinfo.cgi/sepsisgroups-sepsisgroups.org or, via email, send a message with subject or body 'help' to [email protected] You can reach the person managing the list at [email protected] When replying, please edit your Subject line so it is more specific than "Re: Contents of Sepsisgroups digest..." Today's Topics: 1. Blood Cultures from Central Lines (Angela Craig) ---------------------------------------------------------------------- Message: 1 Date: Fri, 31 Jul 2015 08:02:08 -0500 From: Angela Craig <[email protected]> To: "'[email protected]'" <[email protected]> Subject: [Sepsis Groups] Blood Cultures from Central Lines Message-ID: <343E31412FC9094487B54371286ADDA03532BCF20C@D109EXCHMB.crmchealth.hospital> Content-Type: text/plain; charset="utf-8" Is everyone out there getting one set of blood cultures from the central line if the line has been placed >48 hours? per the guidelines (see below)? If so - have you seen an increase in your CLABSI rates due to the risk of false positive blood cultures when collected from the line?? Anyone getting encouragement from Infection Control to only get cultures if the line is the suspected source per IDSA/CDC guidelines?? C. Diagnosis 1. Cultures as clinically appropriate before antimicrobial therapy if no significant delay (> 45 mins) in the start of antimicrobial(s) (grade 1C). At least 2 sets of blood cultures (both aerobic and anaerobic bottles) be obtained before antimicrobial therapy with at least 1 drawn percutaneously and 1 drawn through each vascular access device, unless the device was recently (<48 hrs) inserted (grade 1C). Angela Craig APN, MS, CCNS CNS for ICU Cookeville Regional Medical Center 931-783-5035 This email message has been delivered safely and archived online by Mimecast. For more information please visit http://www.mimecast.com -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://lists.sepsisgroups.org/pipermail/sepsisgroups-sepsisgroups.org/attachments/20150731/b05793a4/attachment.html> ------------------------------ Subject: Digest Footer _______________________________________________ Sepsisgroups mailing list [email protected] http://lists.sepsisgroups.org/listinfo.cgi/sepsisgroups-sepsisgroups.org ------------------------------ End of Sepsisgroups Digest, Vol 165, Issue 4 ******************************************** _______________________________________________ Sepsisgroups mailing list [email protected] http://lists.sepsisgroups.org/listinfo.cgi/sepsisgroups-sepsisgroups.org
