Gilman,

These questions need to be addressed.

thank you,

George Kramer, PhD
Professor
Director Resuscitation Research Lab
Dept. of Anesthesiology
UTMB, Galveston
409-939-3040

On Sep 15, 2015, at 11:25 AM, Allen, Gilman B 
<[email protected]<mailto:[email protected]>> wrote:

Sean,

I attended your webinar on Sepsis Core measures last week and was left with a 
number of concerning questions:

1. If we are using the logic that “there is no evidence to show it doesn’t 
hurt” to justify follow-up physical exam measures for evaluation of response to 
resuscitation, then why does the same logic not apply to the use of Normsol and 
other chloride-balanced crystalloids? I would argue that there is a growing 
body of evidence that normal saline may indeed “hurt” (JAMA. 
2012;308(15):1566-1572.; Br J Surg 102 (1):24-36. Crit Care Med 2014; 
42:1585–1591.

2. In defending the use of many of these unproven metrics of volume 
responsiveness and distal perfusion, you described many of these measures as a 
“proxy” measure of “attentive evaluation” and intensive care.  I full agree, 
and practice this way.  I believe these measures help represent a collective 
epi-phenomenon of intensive and regimented care. Using the same reasoning, why 
then is there no provision in any of this for providers to document their own 
rationale for diverging from some of these restrictive mandates when judged to 
be clinically justified. Is this not also a worthy “proxy” of intensive and 
attentive care?

3. When does the clock really start ticking? Our hospitals still don’t have a 
solid and reliable answer to this question. Is it when the physician documents 
their suspicion of sepsis, 3 hours after a fever and hypotension? When blood 
cultures are first ordered one hour after the fever? Or when an MD orders 
Tylenol, a CBC, lactate, and blood cultures on someone he/she suspects may be 
either bleeding, in pain, or possibly infected post-Op? When do these types of 
patients really “declare” themselves septic.

The efforts to try to “capture” every element of Goal-directed care in an 
“all-or-none” pass/fail algorithm dooms itself from the beginning. Why didn’t 
CMS just start off with the 3 hour bundle, monitor how others do with the 6 
hour bundle, and try to figure out where (and why) their algorithm is 
succeeding, or failing, to capture (and enforce) best practice?

I’ve augured to my group that there is absolutely no excuse for not getting 
blood cultures, a lactate, and fluids on board within one hour of a high 
suspicion of sepsis. This is a low bar we should all be meeting, but probably 
aren’t. Why not simply start there, and work our way forward?

Gilman B. Allen, MD
Associate Professor
Department of Medicine
Director of Adult Critical Care Services
University of Vermont / Fletcher Allen Healthcare
HSRF 220, 149 Beaumont Ave
Burlington, VT 05405-0075
(802)656-9004
Fax: (802) 656-8926
[email protected]<mailto:[email protected]>

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