Marshal,
     From everything I have read the one reason they have trouble curing lyme 
after it goes chronic is that many of the abx do not cross the blood/brain 
barrier.  There is proof though that the lyme bacteria does get in the brain 
and that is why many people have symptoms similiar to alzheimers.  Here is 
some info reprinted  from Dr. Burrascano's Protocal on Lyme.........

SPECT scanning of the brain, if done by knowledgeable radiologists using 
high-resolution equipment, will show characteristic abnormalities in Lyme 
encephalopathy. This not only helps with the differential diagnosis, but if 
done before and after acetazolamide, it will guide in the use of 
vasodilators, which may clear some cognitive symptoms. Therapy can also 
include serotonin agonists, pentoxiphylline and even Ginko biloba. 
Therapeutic trials may be needed. 


If you would like to understand more on Lyme disease here is the address for 
his whole protocal. 
http://www2.lymenet.org/domino/file.nsf/UID/guidelines#INTRODUCTION

Yep, Marshal I would say that it does cross the barrier.
Janis


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