Norton, Steve wrote:
Ok, I am responding to my own query. If I have something wrong, let me
know. This may only be an exercise without use except as my attempt to
understand CS and it's limits as best as I can. What I have found:
* Nothing on the permeability limits of sublingual although I
expect it to be less than the intestinal permeability.
* The permeability of the intestines allows the passing of
molecules up to 9200 Daltons, typically.
* While Daltons is a measure of molecular weight, 9200 Daltons
roughly equates to 13 Angstroms.
* As a sanity test, NaEDTA is used to measure intestinal
permeability. Being a relatively large molecule (approximately
11 Angstroms) it has roughly a 5% (to maybe 18%) absorption
rate. One can measure the levels of NaEDTA in the blood stream
against the expected amount that should have been absorbed and
determine if the permeability of the intestines is to high or
too low. This correlates well with the previous statement.
* CS with a yellow color has particle sizes in the .01 to .001
micron (10 to 100 Angstroms).
* This would mean that most if not nearly all the CS particles in
a yellow batch is not absorbable by the digestive system.
(assuming a symmetrical distribution such as an even or Gaussian
distribution)
* There are factors such as pH and electrical charge that can
increase or decrease absorption.
* This would also mean that little CS is absorbed sublingually.
Comments? Ideas?
- Steve N
-----Original Message-----
From: Norton, Steve [_mailto:[email protected]_]
Sent: Thursday, September 04, 2008 8:06 AM
To: [email protected]
Subject: CS>Particle size
Does anyone know what the maximum size particle is that can be
absorbed into the body either sublingually or through the stomach and
intestines?
- Steve N
Yellow CS has a particle size of from about 160 to 700 angstroms, and
gold color is around 750 angstroms.
Here is some good data, from Analytical Biochemistry 262, 157-176 (1998)
"Light Scattering Submicroscopic Particles as Highly Fluorescent Analogs
and Their Use as Tracer Labels in Clinical and Biological Applications"
by Juan Yguerabide and Evangelina E. Yguerabide:
Absorption peak in nm - absorption color - transmission color for Silver
particles with a diameter in nm of:
38 - 431 nm - violet - yellow
47 - 440 nm - violet - yellow
60 - 449 nm - blue-violet - yellow
75 - 465 nm - blue - yellow/orange
90 - 488 nm - blue - pink
118 -527 nm - green - pink
144 - 590 nm - yellow/green - brown
186 - 465 peak but has a tail of 90% of the peak the extends beyond 700
nm - blue, green, yellow, orange and red - violet
http://www.springerlink.com/content/3755165166601127/ tells us that at
10 nm diameter the absorption peak is at 395 nm, which is in the near uv
range.
Now a nm is 10 Anstroms or 1/1000 of a micron.
A least squares fit applied to this data gives the following equation
for peak wavelength absorbed vs particle size of:
y = 0.0000797254 x^3 + -0.0131913 x^2 + 1.70651x + 379.539
Marshall
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