Dear List, There is a bit of difference between Gold salts used in drugs and Colloidal Gold, (source of information is Wikipedia (I believe the bulk of information which I am responding was derived from Wikipedia)
Two gold drugs remain in active clinical use for this purpose in the United States: sodium aurothiomalate (gold sodium thiomalate) and Aurothioglucose, sold under the trade names Myochrysine and Solgonal, respectively. In the United Kingdom, only sodium aurothiomalate and auranofin are used. Gold thioglucose features gold in the oxidation state of +I, like other gold thiolates. It is a water-soluble, non-ionic species that is assumed to exist as a polymer Under physiological conditions, an oxidation-reduction reaction leads to the formation of metallic gold and sulfinic acid derivative of thioglucose. 2 AuSTg → 2 Au + TgSSTg TgSSTg + H2O → TgSOH + TgSH 2 TgSOH → TgSO2H + TgSH Overall: 2 H2O + 4 AuSTg → 4 Au + TgSO2H + 3 TgSH (where AuSTg = gold thioglucose, TgSSTg = thioglucose disulfide, TgSO2H = sulfinic acid derivative of thioglucose) Disodium aurothiomalate is a chemical compound with the formula AuSCH(CO2Na)CH2CO2Na. In conjunction with its monoprotonated derivative, this coordination complex or closely related species are used to treat rheumatoid arthritis, under the tradename Myochrysine. In vitro experiments have shown that Au(I) can inhibit lymphocyte proliferation, lysosomal enzyme release, the release of reactive oxygen species from macrophages, and IL-1 production. Gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. In former times gold salts were used as second-line drugs (used when the arthritis progressed in spite of antiinflammatory drugs). Nowadays such former "second-line" drugs are used from the beginning of therapy to inhibit joint erosion if possible. The salt CsNa2Au2T(TH) salt (T = thiomalate3-, TH = monoprotonated thiomalate2-) is related to disodium aurothiomalate but is easier to crystallise and characterise by X-ray crystallography. The compound is polymeric with Au-S-Au-S... chains with succinoyl groups attached to the sulfur atoms. Sodium aurothiosulfate is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic linear coordination complex of gold(I) bound to two thiosulfate ligands. Like several other gold compounds, this species is used as an antirheumatic. Colloidal gold, also known as "nanogold", is a suspension (or colloid) of sub-micrometre-sized particles of gold in a fluid — usually water. The nanoparticles themselves can come in a variety of shapes. Spheres, rods, cubes, and caps are some of the more frequently observed ones. Colloidal gold has been successfully used as a therapy for rheumatoid arthritis. Homeopathic Gold, Aurum Metallicum was for the following: Mind.--Feeling of self-condemnation and utter worthlessness. Profound despondency, with increased blood pressure, with thorough disgust of life, and thoughts of suicide. Talks of committing suicide. Great fear of death. Peevish and vehement at least contradiction. Anthropophobia. Mental derangements. Constant rapid questioning without waiting for reply. Cannot do things fast enough. Oversensitiveness; to noise, excitement, confusion.Head.--Eyes.-- Bones.--Destruction of bones, like secondary syphilis. Pain in bones of head, lumps under scalp, exostosis with nightly pains in bones. Caries of nasal, palatine and mastoid bones. Soreness of affected bones, better in open air, worse at night. The rest is at http://homeoint.org/books/boericmm/a/aur.htm There is no listing for Gold at The Agency for Toxic Substances & Disease Registry. There is a listing for Silver. Regards, Steve FossExtreme photophobia. Great soreness all about the eyes and into eyeballs. Double vision; upper half of objects invisible. Feel tense. Sees fiery objects. Violent pains in bones around eye. Interstitial keratitis. Vascular cornea. Pains from without inward. Sticking pains inward. Trachoma with pannus.Violent pain in head; worse at night, outward pressure. Roaring in head. Vertigo. Tearing through brain to forehead. Pain in bones extending to face. Congestion to head. Boils on scalp. -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Address Off-Topic messages to: [email protected] The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <[email protected]>
