Since someone was discussing fungal infections recently I thought this
article was timely. I got this via email this morning.
Antifungal Pepper Compound Has Potential in Agriculture and Medicine
___________________________________________
ARS News Service
Agricultural Research Service, USDA
Rosalie Marion Bliss, (301) 504-4318, [email protected]
July 9, 2009
--View this report online, plus photos and related stories, at
www.ars.usda.gov/is/pr
___________________________________________
Dried, ground cayenne peppers have been spicing up cuisine for thousands of years. Now, Agricultural Research Service (ARS) scientists and colleagues have found that a patented antifungal plant compound in cayenne, called CAY-1, holds promise for dual use as an antifungal in both agriculture and medicine.
The substance is believed to work by attaching to fungal membranes, where it causes cell components to leak, eventually killing the cell. CAY-1 may also enter fungal cells, and adversely affect certain signaling pathways that, in turn, damage the mitochondria-the powerhouses for several cellular processes-in cells.
Anthony De Lucca, a microbiologist with the Food and Feed Safety Research Unit
at the ARS Southern Regional Research Center (SRRC) in New Orleans, La., led a
study in which he and colleagues isolated 10 fungi-either primary or secondary
grape pathogens-from diseased grapes grown in a hot, humid environment. Primary
pathogens directly cause infection, whereas secondary pathogens infect after
the hosts's defenses have been compromised by stress, injury, or other
infection.
They tested CAY-1 against these fungi in the laboratory. CAY-1 was lethal
during the early spore germination cycle of seven of the fungi, but was
inactive against dormant spores. While CAY-1 was lethal to the grape
pathogens, additional research is required to indicate if, and how, the
compound could be used safely on grapes. This work was published in the
American Journal of Enology and Viticulture.
The SRRC researchers also have collaborated with physician Thomas Walsh and others at the National Institutes of Health (NIH) in Bethesda, Md., to study CAY-1 activity against Microsporum canis and Trichophyton rubrum, which are skin fungal pathogens that infect immune-compromised individuals. The study showed that CAY-1 is active in the laboratory against these skin pathogens. That study was published in the journal Medical Mycology.
Read more about this research in the July 2009 issue of Agricultural Research
magazine, available online at:
http://www.ars.usda.gov/is/AR/archive/jul09/mold0709.htm.
ARS is the principal intramural scientific research agency of the U.S.
Department of Agriculture.
Annie
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