our cataract research mentioned the application of 100%, undiluted DMSO. While we have never encountered any case where the external....or internal....use of undiluted DMSO has resulted in ANY measurable degree of tissue compromise----there ARE circumstances where the result of such application has a PRONOUNCED rush of marked discomfort. The burning sensation resulting from such protocols is, sometimes, called "false blister", as it feels almost identical to a pronounced sunburn. A majority of all such incidents (among those we have encountered) result from a single cause.....which is the immediate rush of DMSO responding to its powerful hygroscopic character. The actual effect of introducing pure/undiluted DMSO will vary---sometimes, remarkably so----
based upon the fact that the actual volume/availability of moisture existing in the eye socket at the time of application varies widely among persons.....many times as much as 50%. Such conditions set the stage for a most uncomfortable reaction.....at the precise moment of introducing the DMSO to the eye surface/socket environment. The less the volume of existing moisture/tears present at this moment.....the more pronounced the potential discomfort to the recipient. I repeat myself from earlier cautions: DMSO is EXTREMELY hygroscopic, to the extent that in some cases, if inadvertently having water poured into the vessel containing the parent, undiluted, DMSO....The reaction is so violent that liquid material will be ejected in the form of large bubbles/mist----together with the generation of pronounced heat. Even when mixed properly with other liquids containing water fractions....DMSO ALWAYS causes a reaction which liberates heat.
We have failed to encounter many circumstance where solutions containing DMSO, require strengths beyond 20%....and in most cases, not beyond 10%. Exceptions include normal, external, non-abraded, skin tissues.
I do not mean to "gild-the-lily" with these comments, but do feel they are worth ones consideration. Especially in view of the fact we have such a wide disparity in technical/biological and chemical knowledge among the list membership.
I consider ALL members to be intelligent.....but not equally informed.
Sincerely, Brooks Bradley.
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