I have done some research and use of EDTA. At the risk of just confusing matters more, I will give some of my opinion/experience with EDTA. (I have bulk powdered forms of Calcium, Disodium and Tetrasodium EDTA.) There are many more forms of EDTA than just calcium and sodium. The question is what forms are available and useful. Calcium EDTA has the most scientific documentation is the most widely used type. It is considered safe to use within reasonable limits. Magnesium EDTA is claimed by some to be more effective if you want to remove calcium from the body but it is harder to get and may be illegal in the US as a dietary supplement. Various forms of sodium EDTA are widely available. Personally, I think all work and that the significant differences between each type is the issue of bioavailability. The primary factor influencing the bioavailability of EDTA, IMO, is solubility of the EDTA. The solubility of EDTA is mostly determined by the pH in the digestive tract. The pH of the digestive tract normally varies between 1 to 8. See:
http://www.chemcases.com/pheno/pheno14.htm "The pH of the stomach in a normal, healthy human is in the 1-3 range. There are many purposes for the high acidity found in the stomach. One of the main functions of the high acid content is to destroy bacteria that are ingested. Few bacteria can survive in an environment with a pH of 1 to 3! Some do, though, because on an impenetrable outer coat that can resist acid breakdown. Another purpose for such a low pH is that high acidity is required to activate pepsinogen. Pepsinogen is the enzyme that initiates the digestion and breakdown of proteins that are ingested. The other major component of gastric fluid is mucus. Mucus provides protection to the stomach lining from the high acid content. Gastric pH varies from time to time. Gastric acid is secreted in anticipation of a meal, to prepare for digestion. Gastric pH decreases as a result of acid secretion, and, after a heavy meal, blood pH correspondingly increases, particularly in those segments of the circulatory system associated with supplying the gastrointestinal tract. This increase in blood pH is known as the "alkaline tide", and is caused by bicarbonate ions that are secreted into extracellular fluid of the stomach, then into venous blood. Further down the alimentary canal is the small intestine, the first part of which is the duodenum. The pH of the duodenum is 6 to 6.5. The majority of nutrients, vitamins, and drugs are absorbed in this 6 inch area of the gastrointestinal tract. In addition to water, mucus, and electrolytes, secretions from the liver and pancreas join secretions from the intestinal mucosa to facilitate digestion and absorption. The anatomy of the small intestines is such that a very large surface area that provides better absorption is available. The lining of the small intestines is composed of many villi, or finger like projections, which extend even more as projections called the brush border. The area is highly perfused with blood. These factors contribute to a very high surface area, increasing the likelihood of drug absorption taking place, if the ionization criterion is met. The pH can reach 7 to 8 in this area. Further along the small intestine, beyond the duodenum, lies the jejunum and ileum. These sections of the small intestine lack the high surface area of the duodenum and only small amounts of absorption across the lipid membranes occurs in this section of the small intestine. As we get further away from the stomach, the pH rises to about 7.5 in this region. And the final organ of the digestive tract is the large intestine, which includes the colon and rectum. The large intestine is the site for water resorption and the production of feces. Seldom does drug absorption take place in this region. The pH of the large intestine is 5.5-7, and like the buccal area, blood that drains the rectum is not first transported to the liver. So, absorption that takes place in the rectum (from rectal suppositories and enemas) goes into the systemic circulation without biotransformation that takes place due to liver enzymes." For Calcium and Disodium EDTA it takes a ph of 8.0 or above for it to dissolve. And it takes a long time at 8.0 to dissolve. Tetrasodium EDTA dissolves in the pH range of 6 to 9 and dissolves rather quickly. Studies show that only about 5% of orally ingested Calcium EDTA enters the blood stream. But a paper was published in JAMA that showed a 36% absorption rate if taken as a suppository. See: "Comparison of the Absorption, Brain and Prostate Distribution, and Elimination of CaNa2 EDTA of Rectal Chelation Suppositories to Intravenous Administration." (http://www.detoxamin.com/documents/EllithorpeReprint10_2.pdf) Given that the pH of the large intestine is only 5.5-7, I am somewhat surprised at the high absorption rate of the suppository. Perhaps they do something to increase the solubility of the EDTA in the suppository. The cost of the suppository is relatively high. CaNa2 EDTA is easy to buy as a powder and you can make your own suppository. (CaNa2 EDTA is Calcium Disodium EDTA and is often shortened to just Calcium EDTA) Look online for instructions. I think that a suppository is the way to go if you can. I use Tetrasodium EDTA because of it's solubility at a lower pH. While I have and use the bulk powder, it is available as a liquid called Cardio Renew, http://www.cardiorenew.com/index.php, and possibly from other suppliers as well. - Steve N -----Original Message----- From: Annie B Smythe [mailto:[email protected]] Sent: Sunday, November 22, 2009 11:38 PM To: CS List Subject: CS>Questions about EDTA Hello the list :) I've been boning up on EDTA and I understand there are two forms. Calcium EDTA and Sodium EDTA, so does anyone know which one is the best? I've read good and bad about both. Has anyone here on the list used either one of them? And how would that effect a daily dose of CS, if they pull metals? I am not well versed in chemistry, sigh. It is one of the few sciences I never studied in high school, or college. I know when to call it quits and holler for help. : D I read some ignorant person's comment that EDTA pulls metals and gets rid of them through the kidneys. That was ok, Cilantro does the same thing, chlorophyll uses the GI tract. Then they stated the kidneys aren't the way the body eliminates stuff. I just sat there and stared for a minute or two in disbelief. I couldn't believe they actually wrote that. Pfffft, physiology is one thing I do know; the kidneys, the skin, and the intestinal tract are elimination organs. That erroneous statement shows how ignorant this person is. Now I don't believe anything they say because they obviously don't know how the body works, whether they sound like they do or not. I got so aggravated with their self righteous pontificating when they don't even understand body functions, I closed the tab. But I've still got all these pages and pages of pros and cons, and I have no idea who is just repeating stuff, and who really knows what they're talking about. Well unless them give themselves away like that one did. Help, please? Annie -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Address Off-Topic messages to: [email protected] The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <[email protected]>
