2 parts didn't work so now ther will be 3 parts. - Steve N
Vitamin B3. Vitamin B3 acts on the tau protein.The Vitamin B3 study was performed on rats. UC Irvine is currently seeking volunteers for a human clinical trial. Here is a link to an abstract of the Vitamin B3 study: Nicotinamide Restores Cognition in Alzheimer's Disease …The Journal of Neuroscience, November 5, 2008 http://www.jneurosci.org/cgi/content/abstract/28/45/11500 Here is a link to the UC Irvine announcement on the study they performed: Vitamin B3 reduces Alzheimer's symptoms, lesions http://today.uci.edu/iframe.php?p=/news/release_detail_iframe.asp?key=1849 Here are a couple of good articles on the UC Irvine study: High Doses of Vitamins Fight Alzheimer's Disease http://orthomolecular.org/resources/omns/v04n25.shtml Alzheimer’s Disease and a Possible Cure http://dickshealthdebate.blogspot.com/2009/05/alzheimers-disease-and-possible-cure.html High dose vitamin B3 has also been found beneficial in some cases of diabetes and schizophrenia: Another Anecdote of Schizophrenia http://www.doctoryourself.com/hoffer_anecdote.html Curcumin. Curcumin acts on the amyloid accumulation. Because of this I think it makes a complementary treatment with B3. Additionally, curcumin has many other health benefits including helping to prevent some types of cancers. Curcumin is found naturally in the spice turmeric which generally contains 3 to 5% curcumin. You can buy standardized extracts of curcumin, usually 90 – 95% curcumin. But I prefer to make my own turmeric tinctures and just use enough to get the necessary amount of curcumin. I also believe that whole herb tinctures that contain all the plant substances are generally better than isolated extracts.Because the body metabolizes curcumin so quickly, bioavailability is a problem with curcumin. (See: Bioavailability of Curcumin: Problems and Promises http://mccormickscienceinstitute.org/assets/Mol%20Pharm.%202007%20Nov_Dec;4(6)807-18.pdf) But there are some products out there that give improved bioavailability.As far as I know, there are 3 forms of improved bioavailability curcuman available commercially: 1. Curcuman with Bioperene (aka pepperine) (A number of sources are available) 2. Biocurcumax - Curcuman blended with turmeric oil (an essential oil). 3. Lipisomal encapsulated curcuman A number of sources are available. Biocurcumax is more more bioavailable than curcuman with Bioperene and lasts roughly twice as long in the bloodstream (8 hrs).I haven't seen data on Lipisomal encapsulated curcuman but my guess is that it is equivalent to Biocurcumax.You can mix freshly ground black pepper with curcuman (or turmeric) to get something similar to Curcuman with Bioperene.You can mix curcuman with turmeric oil to get something similar to Biocurcumax I use a homemade combination of pepperine, turmeric oil and DMSO combined with a turmeric tincture.Here is a link to the curcumin study: Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo http://www.jbc.org/content/280/7/5892.full
