We have not conducted any dedicated studies directly evaluating ALA, either singly or in combination...for lingual nerve insults.
However, I have had some personal experiences with the benefits of ALA for facial neuralgia, associated with upper tooth problems. 1000 mg of ALA daily, furnished me with complete relief in about 48 hours (the pain from the neuralgia was VERY intense from the initial insult). Before instituting the ALA component, no acceptable relief appeared from any protocol introduced. Some, small, degree of pain relief was achieved----in the beginning---from Ibuprofen-type analgesics....but this was short-lived and required unacceptably-high dosages. Some relief was achieved utilizing 4% lidocaine...in a topical setting....as an address to the more intolerable episodes. This was, always, a last-ditch effort.
Later, I added Methyl B-12 to my 500 mg ALA daily prophylactic protocol. Presently, I maintain a i1000 mcg of sublingual Methyl B-12 and 400 mg of ALA (for several reasons, not just for neuralgia).
My personal inquiries from other researchers seems to confirm the individual variation in effective minimum prophylactic dosages of both ALA and B-12.....required to relieve/maintain control parameters---- for varying types of neural trauma.
One observation: I am aware of some cases that required substantial dosages of both ALA and B-12 introduced via IV.....in order to achieve rapid relief, for presentations of severe pain among test subjects. This was especially so
in some diabetic-related scenarios.
I apologize for being unable to furnish you more useful information. You have my genuine sympathy and good wishes for a rapid and complete resolution of your condition. I can testify, personally, to the degree of discomfort caused by your condition.
Best Regards, Brooks.
---------[ Received Mail Content ]----------
Subject : Re: CS>Burning Feet: Extended Commentary.
Date : Sat, 23 Jan 2010 21:59:43 -0800
From : "Bob Banever" <[email protected]>
To : <[email protected]>
Brooks,
Have you done or do you know of any studies done on lingual nerve damage with resultant paresthesia/dysesthesia? I have burning pain on the right side of my tongue from an injection of articaine 30 months ago. I'm wondering if B1, B12, and ALA might give me some relief or if you've heard of any other protocol that might help. Looking forward to your response.
Bob
----- Original Message -----
From: Brooks Bradley
To: [email protected]
Sent: Saturday, January 23, 2010 2:47 PM
Subject: CS>Burning Feet: Extended Commentary.
Now that my, original, comment has come through...I will conclude my comments on this topic.
First, however, I wish to rectify a misstatement made in my earlier post (caused by haste....I trust).
In the concluding paragraphs I commented on two improved types of B-12....as being presently available. This was
in error. Actually, what I meant to say that there were " two improved members of the vitamin B family" presently available.
They are Benfotiamin (a B-1 form), which greatly improves cell penetration...and is a pronounced improvement over most of the earlier representatives of the B-1 family. This B-1 form has demonstrated to be a noticeable improvement over earlier types
offered by the commercial market. The beneficial effects...especially for challenges presented by diabetes complications---
are quite striking. Benfotiamin and Methyl B-12 demonstrate to act in synergistic manner ....when used simultaneously----as
a peripheral neuropathic protocol.
The other vitamin is Methyl B-12 (methylcobalamine). This form is MUCH more soluble to tissue...than is the standard cobalamine form. Methyl-cobalamine is, also, quite effective as an ancillary protocol for autism in children (most especially below the age of 10 years).
This substance is well-tolerated by a majority of the general population, and oral ingestion is quite effective and adequate for maintaining satisfactory blood titers. Although IV was, is, more immediately effective....and more completely utilized....than is sublingually ingested forms of Methyl B-12......the sublingual administration shows to be about 50% as active (by volume), as are IV administrations. (At least that has been our experience).
We were privy to studies conducted by other research organizations, which revealed some very powerful effects of B-12 upon diabetic related peripheral neuropathy insults. e.g. One study revealed that IV injections of 2500 mcg of B-12 provided very substantial control/improvement in neuropathy presentations. Presenting symptoms (burning, itching, coldness, etc.) were well-resolved----sometimes in hours, and did not require other injections for intervals of...sometimes....as great at 3 months. In some cases the "standard" protocol of 2500 mcg IV once each month was many times, soon extended to once every 3 months.....and in some cases to several years in time.
As Alpha Lipoic Acid was unknown (to us) as an available address for diabetes-related peripheral neuralgia....at the time of our investigations.....no data was available to us---at that time--- on ALA beneficial effects. However, since the 1998-99 time frame, we have accumulated a sizable data base on the positive influence of ALA on peripheral neuralgia. Our recent investigations have, sometimes, shown "stunning" and immediate (within hours on occasion) relief. The most profound effects related to burning/itching of the feet and toes. A majority of these "experimental investigations" required 800 to 1000 mcg (minimum) to effect such rapid responses.
We did not observe a single case of negative "side-effects" from the higher volumes of ALA.......used by the experimental volunteers.
I hope these comments prove to be of some value to list members conducting their own experimental researaches.
Sincerely, Brooks Bradley.
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