Colloidal Silver
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Colloidal Silver: 
Risk Without Benefit
Stephen Barrett, M.D.
Colloidal silver is a suspension of submicroscopic metallic silver particles in 
a colloidal base. Long-term use of silver preparations can lead to argyria, a 
condition in which silver salts deposit in the skin, eyes, and internal organs, 
and the skin turns ashen-gray. Many cases of argyria occurred during the 
pre-antibiotic era when silver was a common ingredient in nosedrops. When the 
cause became apparent, doctors stopped recommending their use, and reputable 
manufacturers stopped producing them. The official drug guidebooks (United 
States Pharmacopeia and National Formulary) have not listed colloidal silver 
products since 1975.

Dubious Ads
In recent years, silver-containing products have been marketed with 
unsubstantiated claims that they are effective against AIDS, cancer, infectious 
diseases, parasites, chronic fatigue, acne, warts, hemorrhoids, enlarged 
prostate, and many other diseases and conditions. Some marketers claim that 
colloidal silver is effective against hundreds of diseases.

During 1998, a Florida-based multilevel company, stated:

  Our colloidal silver contains 99.99% pure silver particles suspended 
indefinitely in demineralized water that kills bacteria and viruses. It can be 
applied topically and/or absorbed into the blood stream sub-lingually (under 
the tongue), thereby avoiding the negative effects of traditional antibiotics 
that kill good bacteria in the lower digestive tract.

  An all natural antibiotic alternative in the purest form available. The 
presence of colloidal silver near a virus, fungi, bacterium or any other single 
celled pathogen disables its oxygen-metabolism enzyme, its chemical lung, so to 
say. The pathogens suffocates and dies, and is cleared out of the body by the 
immune, lymphatic and elimination systems.

  Unlike pharmaceutical antibiotics which destroy beneficial enzymes, colloidal 
silver leaves these beneficial enzymes intact. Thus colloidal silver is 
absolutely safe for humans, reptiles, plants and all multi-celled living matter.

  It is impossible for single-celled germs to mutate into silver-resistant 
forms, as happens with conventional antibiotics. Also, colloidal silver cannot 
interact or interfere with other medicines being taken. Colloidal silver is 
truly a safe, natural remedy for many of mankind's ills. Colloidal silver can 
be taken indefinitely because the body does not develop a tolerance to it [1]

Seasilver Intermational, a California-based multilevel company, claims that 
American are suffering from "silver deficiency." Although silver is not an 
essential nutrient, product information posted on the company's Web site states:

  The depletion of minerals in our soil has left us deficient of silver, one of 
our most essential trace minerals, causing a drastic increase in immune system 
disorders in our society in the last decade. Research has taught us that all 
disease is allowed to manifest itself because of a weakened immune system. In 
over 20 years of worldwide research on Colloidal Silver, numerous interviews 
with government agencies, health care practitioners and their patients, no 
other nutrient, herb or drug (prescription or over-the-counter) is as safe and 
effective against all known forms of unfriendly virus, bacteria, and fungus. 
Additionally, while it is generally known that most antibiotics kill only 
perhaps 6 or 7 different disease organisms, reports have shown that Colloidal 
Silver has been used successfully in the treatment of over 650 diseases! 
Furthermore, strains of disease organisms fail to develop in the presence of 
Colloidal Silver. Colloidal Silver's greatest attribute is its unique ability 
to function as a superior second immune system in the body! [2]

The ad below is from the July 1996 issue of Alternative Medicine Digest.



Critical Studies
In 1995, an herbal distributor named Leslie Taylor tested nine commonly 
marketed colloidal silver products available at health-food stores and 
concluded:

  a.. Two of the products were contaminated with microorganisms. 
  b.. The amount of silver suspended in solution varied from product to product 
and would gradually decrease over time. 
  c.. Only five products actually showed antibacterial activity in a laboratory 
test. To perform the test, she prepared a culture plate with Staphylococcus 
aureas bacteria, which can cause infections in humans. She then placed a drop 
from each product on the plate and used disks of two common antibiotics as 
controls. After eight hours of incubation, she found that bacterial growth had 
been inhibited around the antibiotics and four of the products. 
Of course, the fact that a product inhibits bacteria in a laboratory culture 
doesn't mean it is effective (or safe) in the human body. In fact, products 
that kill bacteria in the laboratory would be more likely to cause argyria 
because they contain more silver ions that are free to deposit in the user's 
skin. .

FDA laboratory studies have found that the amount of silver in some product 
samples has varied from 15.2% to 124% of the amount listed on the product 
labels. The amount of silver required to produce argyria is unknown. However, 
the FDA has concluded that the risk of using silver products exceeds any 
unsubstantiated benefit [3].

In October 1996, the FDA proposed to ban the use of colloidal silver or silver 
salts in over-the-counter products [4]. A Final Rule banning such use was 
issued on August 17, 1999 and became effective September 16th. The rule applies 
to any nonprescription colloidal silver or silver salt product claimed to be 
effective in preventing or treating any disease [5]. Silver products can still 
be sold as "dietary supplements" provided that no health claims are made for 
them.

References
  1. The company (Changes International) is no longer in the supplement 
business. 
  2. Seasilver International Product Information, accessed October 12, 1998. 
  3. Fung MC, Bowen DL. Silver products for medical indications: risk-benefit 
assessment. Journal of Toxicology and Clinical Toxicology 34:119-26, 1996. 
  4. Federal Register 61:53685-53688, 1996. (To access this document, search 
the 1996 volume for "colloidal silver.") 
  5. FDA. Final rule: Over-the-counter drug products containing colloidal 
silver ingredients or silver salts. Federal Register 64:44653-44658, 1999. 
Download PDF version 
For Further Information
Rosemary Jacobs, an argyria victim, has made a detailed study of the colloidal 
silver marketplace and is willing to answer questions. 

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This article was updated on November 5, 1999.