On Tue, 4 Sep 2001 09:20:39 EDT, [email protected] wrote:

>I HAVE A QUESTION REGARDING THE United States of America Environmental 
>Protection Agency Recommendations, From Federal Register, Vol., 56, No. 20, 
>30 January 1991, p3573, Silver:  
>Derivation of SMCL for Silver 
>The cosmetic DWEL is calculated assuming 1g of silver administered I.V. will 
>produce a mild argyria in the most sensitive individuals (Gaul and Staud, 
>1935; Hill and Pillsbury, 1939). Assuming 4 percent absorption of silver 
>(Furchner et al., 1968) following oral exposure, the I.V. dose corresponds to 
>an oral dose of 25g (1g/0.04 = 25g). This dose is then averaged over a 
>lifetime, assumed to be 70 years: 

Huh?  What is this craziness?   An I.V. of 1 gram silver produces
*mild* argyria in the *most sensitive* individuals?  That's a whopping
amount of silver -- and it produces mild argyria?  

Most people using CS wouldn't get 1 gram in their lifetime (hmm, I'd
better calculate that out :)  [calculating] 

25,550 days in a lifetime times 0.00001 grams daily (that's 1
liter/quart of 10 ppm CS if it's absorbed 100%) comes out to about 1/4
gram of silver over a lifetime.  Maybe I messed something up, but even
if I'm low by a factor of 10, it's only 2.5 grams of lifetime silver.

And that would be only if the body stored the silver, which it doesn't
(according to tests by Roger Altman).

>Lifetime
>25 g* ---------------------- = 978ug/day
>25,5 50 days
>Based on an adult body weight of 70Kg, this corresponds to 14ug Kg/day (978 
>ug /day / 70 Kg=14 ug /Kg/day). 

What BS!!  


> >>2l/day = assumed water consumption by an adult. 

>Why is it divided by 21 days?  

It's not.  That figure is 2 liters of water per day, not 21 days.
(and we all know that we should be drinking at least 3 liters of water
per day :)

-- Dean -- from (almost) Des Moines -- KB0ZDF


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