By Claire Soares 

                                  WASHINGTON (Reuters) - Humans are building up 
dangerous
                                  levels of resistance to modern antibiotics 
that could leave them
                                  vulnerable to killer diseases, the U.N. World 
Health Organization
                                  said on Tuesday. 

                                  Farmers who use antibiotics to fatten up 
livestock and poultry are
                                  aggravating the problem because microbes on 
animals build up
                                  defenses against the drugs, then jump across 
the food chain and
                                  attack human immune systems, WHO said. 

                                  The world health body said tuberculosis 
strains in several countries
                                  had become resistant to two of the most 
effective drugs and some
                                  antimalarial medicines had become practically 
useless as parasites
                                  adapted their defenses. 

                                  "Antibiotics were one of the most significant 
discoveries of the 20th
                                  century," WHO Director Gro Harlem Brundtland 
said in a statement.

                                  "Unless we act to protect these medical 
miracles, we could be
                                  heading for a post-antibiotic age in which 
many medical and surgical
                                  advances could be undermined by the risk of 
incurable infection." 

                                  The WHO said industry data showed 
pharmaceutical companies had
                                  spent more than $17 billion over the past 
five years on developing
                                  medicines to treat infectious diseases. 

                                  "Unless drug resistance is tackled quickly, 
much of that investment
                                  could be lost," the organization said. 

                                  WHO urged patients, doctors, hospitals, 
farmers and legislators to
                                  take action to contain the threat. 

                                  The body wants farmers to stop using 
antibiotics simply to make their
                                  animals grow, and recommends that when 
animals are ill, their
                                  owners should have a prescription for any 
necessary drugs. 

                                  Human patients should avoid putting pressure 
doctors to give them
                                  antibiotics, the report said. Doctors should 
prescribe drugs
                                  specifically to match a person's illness, 
rather than automatically
                                  giving them the newest or best known 
medication. And hospitals
                                  should develop more stringent monitoring 
systems, it added. 

                                  "This strategy is designed to promote the 
wiser use of drugs so that
                                  resistance is minimized and effective 
treatments can continue to be
                                  used for generations to come," David Heymann, 
director for
                                  communicable diseases, said.