Greetings most August Wizards of the CS art,

 Now then, how on earth can the complexity of life be crammed into a tiny bacterium two-hunderd-millionth the size of a simple amoeba ?
 Again we are faced with a problem in compactness and we must pause to consider the units we are using. When we thought of a brain in terms of pounds, it was a small bit of tissue. When we thought of it in terms of cells, however, it became a tremendously complex assemblage of small units. In the same way, in considering cells, lets stop thinking in terms of cubic microns and start thinking in terms of atoms and molecules.
 A cubic micron of protoplasm (meaning all the "stuff" in a cell) contains about 40,000,000,000 molecules, thats forty billion molecules. Allowing for this, lets remake table two into table three.

   Table 3

         Cell                                          Number of molecules
     Amoeba                                170,000,000,000,000,000
     Human liver cell                              70,000,000,000,000
     Human red blood cell                        3,000,000,000,000
     Human spermatozoon                           680,000,000,000
     Largest bacterium                                  280,000,000,000
     Smallest bacterium                                        800,000,000

 It would be tempting, at this point, to say that the molecule is the unit of the cell, as the cell is the unit of a multicellular organism. If we say that, we can go on to maintain that the amoeba is seventeen million times as complicated, molecularly speaking, as the brain is, cellularly speaking. In that case, the compactness of the amoeba as a container of life becomes less surprising.
 There is a catch, though. Almost all the molecules in protoplasm are water, simple little H2O combinations. These are essential to life, goodness knows, but they serve largely as background. They are not the characteristic molecules of life. If we can point to any molecules as characteristic of life, they would be the complex nitrogen-phosphorus macromolecules: the proteins, the nucleic acids, amino acids, and the phospholipids. These, together, make up only about one ten-thousandth of the molecules in living tissue.
 Now I'm not saying that these macromolecules make up only 1/10,000 of the weight of living tissue; only of the numbers of molecules. The macromolecules are individually much heavier than the water molecules. An average protein molecule, for instance, is some two thousand times as heavy as a water molecule. If a system consisted of two thousand (2,000) water molecules and one (1) average protein molecule, the number of protein molecules would be 1/2001 of the total molecules , but the weight of the protein molecule would be 1/2 of the total weight.
 So lets change table three into  macromolecules that are characteristic of life.

 Table 4

      Cell                                         Nitrogen-phosphorus macromolecules
   Amoeba                                  17,000,000,000,000
   Human liver cell                                7,000,000,000
   Human red blood cell                           360,000,000
   Human spermatozoon                             68,000,000
   Largest bacterium                                    28,000,000
   Smallest bacterium                                           80,000

 We can say then, that the average human body cell is indeed as complex, molecularly speaking, as the human brain, cellularly speaking. Bacteria are markedly simpler than the brain, while the amoeba is markedly more complex.
 Still, even the simplest bacterium grows and divides with great alacrity and there is nothing simple, from the chemical standpoint, about growing and dividing.  That simplest bacterium, just visible under a good optical microscope, is a busy, self-contained and complex chemical laboratory.
 But then, most of the 80,000 macromolecules in the smallest bacterium (lets say 50,000) are enzymes, each of which can catalyze a particular chemical reaction. If there are 2,000 different chemical reactions constantly proceeding within a cell, each of which is necessary to growth and multiplication, then there are, on average , 25 enzymes for each reaction.
 A human factory in which 2,000 different machine operations are being conducted, with 25 men on each machine, would rightly be considered a most complex structure. This is more complex than an automobile assembly plant. Even the smallest bacterium is that complex.
 We can approach this from another angle, also. About the turn of the century, biochemists began to realize that in addition to the obvious atomic components of living tissue (such as carbon, hydrogen, oxygen, nitrogen, sulfur, phosphorus and so on) certain metals were required by the body in very small quantities. They became know as trace elements.
 As an example, consider two recent additions to the list of trace metals in the body, molybdenum and cobalt (remember the sheep story). Now I'm positive that each and every naturally existing element in nature can be found in the body, some are essentially necessary to life, some are just there (pollution) and not harmful, and some are there and are harmful.
 The entire human body contains perhaps 18 milligrams of molybdenum and 12 milligrams of cobalt (roughly one two-thousandth of an ounce each). Nevertheless, this quantity, while small is absolutely essential to the body. The body can not exist without it.

 --to be continued--
 

Bless you  Bob Lee

--
oozing on the muggy shore of the gulf coast
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