Dear Wong,
The dosages you relate appear quite adequate
for general maintenance for individuals with "mild challenges".
Interestingly, we found that a reversal of the percentages of ALA and
ALC you state.....gave the best results. The addition of COQ-10 should
only help. Creatine is not adviseable in some cases......especially in
advanced age volunteers. The reason being that it, sometimes, causes a
condition similar to "anabolic steroid-induced trauma"......in these
sensitive individuals. While creatine has shown to offer excellent
support to the bulk of the population (especially under 55 years,
biological age), some caution should be considered before utilizing for
older volunteers. Reaction tests might be in order----especially if
larger dosages are contemplated for older "non-athletes".
In cases of acute challenge we utilized as much as
1000 mg ALA daily......with excellent results. At these levels we did
use 500 mg of ALC.
A side note you may find of interest; is that we
obtained (in some cases) unusually effective early response among the
most "highly challenged" group.....through using a 10 minute
"pre-conditioning" of O2 (at approximately 80% O2 and 20% atmospheric
air). Although we did not encounter any cases of hyper-ventilation
during the O2 preconditioning protocols......it would be prudent to
remember that if such WERE to occur, just having the volunteer breathe
in and out into
a plain brown paper bag will alleviate the consequences quite rapidly.
Our results using the little artist's air-brush to
deliver the O2 demonstrated to be equally effective......as did
employing a conventional "hospital-type" oxygen-support system. The
hospital-type system is cost-prohibitive-----for most do-it-your-selfer
researchers. An additional result which recommends the simple
air-brush system is that by holding the discharge nozzle just inside the
mouth and closing the lips to within about 1/4" circular clearance
around the air-brush nozzle....a resultant venturi action which pulls
atmospheric air into the gas-stream......completely mitigates against
hyper-ventilation.
Good luck in your personal
researches.
Sincerely, Brooks
Bradley.
[email protected] wrote:
> Dear Brooks
>
> I am not a researcher but if I may, I would like the dosage protocol
> you used.
>
> Here is some information from another list you may be interested in:
> suggested dosage to be taken 3 times a day.
> ALC 500mg
> ALA 250mg
> COQ10 80 mg
> CREATINE 5g.
>
> Costing based on Beyond A Century prices $1.82 per day.
>
> Wong
>
>
> In a message dated 02/26/2002 7:40:45 PM Pacific Standard Time,
> [email protected] writes:
>
>
>
>> I have noticed that there has been,
>> quite recently, some interesting
>> references to possible benefits from using alpha lipoic acid and
>> acetyl-l-carnitine.....in combination. The latest comments
>> originate
>> from the Linus Pauling Institute.
>> Their claim is for an order of magnitude increase in
>> effectivity......over either substance ingested alone. I was VERY
>> interested in their comments----since we have prosecuted a series of
>>
>> mammal-based evaluations......using these very subsances in concert.
>>
>> Our results track----very closely----those claimed by this
>> Institute.
>> We did not deem it necessary to undergo the expense of "Blind
>> Studies"
>> for such an exploratory-type investigation; we, none-the-less, have
>> a
>> substantive confidence there IS merit to this protocol. Through
>> varying
>> the proportions of the two compounds, we have arrived at a tentative
>>
>> assumption that-----alpha lipoic acid is the most powerful
>> progenitor in
>> the combination....and is more powerful in results when combined
>> with
>> much smaller portions of acetyl-l-carnitine-----than when the
>> reverse
>> conditions are manifest.
>> The principal reason for our original interest was based
>>
>> upon our pronounced interest in addressing the challenges of
>> "age-related" insults presenting in humans and other higher mammals.
>>
>> I am, at present, discussing the adviseability of
>> mentioning the dosage protocols we found to be most efficacious. If
>> I
>> can obtain the proper legal assurances, I will.....most
>> probably....post
>> a synopsis of our results to the list.
>> Meantime, I would encourage the membership to
>> conduct----at least---a literature search on this protocol. Such is
>>
>> ESPECIALLY recommended for older researchers suffering from a
>> lowered
>> metabolic level and/or cognition-related challenges----most
>> especially
>> compromises in clearness of thought and ability to maintain a
>> coherent
>> thought pattern.
>> Researchers in SERIOUS straits may contact me
>> off-line
>> for a more extended explanation. Please, no "FISHING
>> EXPEDITIONS".....while healthy, my total energies are limited-----I
>> do
>> wish to utilize them to best advantage.
>> Sincerely, Brooks
>> Bradley.
>>
>>
>> --
>
>
>
