Thanks Ivan. As you say, a big question. Low cellur pH then seems to be a chief cause of cancer initiation. Does that mean that raising cellular pH will reverse the process once cancer has set in? As Terry Chamberlain has pointed out, too high a pH is associated with poor digestion, constipation etc. This creates a dilemna for anyone already experiencing those symptoms (I have on and off) who wants to guard against cancer. A naturopath friends advice to acidify my system by taking lots of lemon juice, and for a while calcium lactate, certainly fixed up a bout of constipation.
regards, Kevin Nolan ----- Original Message ----- From: "I Anderson" <[email protected]> To: <[email protected]> Sent: Sunday, April 07, 2002 10:09 PM Subject: RE: CS>Silver Compounds and electrobiological/electromagnetic response > Hi Kevin, > You ask a BIG question, which requires time to marshal a response. > > "Does anaerobic metabolism cause cancer?" > > Warburg had quite a bit to say about oxygen and cancer, but I am not > sure that he gave an answer to that question. What he did find in > cancerous tissue was impaired or defective mitochondrial processes. It > is in the mitochondria that cellular energy processes occur, normally > by the oxidation of glucose with the products being ATP, CO2 and > water. The process proceeds through a glycolysis phase which produces > a small amount of ATP and lactic acid. The lactic acid would then be > oxidised further with a much larger production of ATP, CO2 and water. > Warburg found that the second phase did not occur in cancer cells, > leading to the rise in concentration of lactic acid (and therefore > lowering of pH), and found that mitochondria was impaired in some way. > I think he believed that a lack of oxygen caused mitochondrial damage, > but others disagree, the fact remains, however, that where there is > lactic acid build there is anaerobic energy production, whether this > is in the presence of oxygen or not. > > What causes a cell to become cancerous in the first place is the > mutation of dna (be it cellular or mitochondrial) or some impairment > of cellular process, notably the expression or manufacture of proteins > and enzymes, from nucleotide building blocks. A normal pH ensures the > breakdown glucose into the A, C, G and T nucleotide radicals that > promote healthy DNA synthesis, and severely limits the ability of > mutagens to cross the cellular membrane where they might cause some > mutation. If the extracellular plasma is more acidic than optimum the > intracellular fluid must also drop below normal (pH6.6) to maintain > the appropriate potential across the cellular membrane, not only does > this allow the passage of mutagens, but also impairs proper nucleotide > production. These events may cause cells to mis-function and develop > cancer. When the pH of a cancerous cell lowers sufficiently, the pores > on the cellular membrane do not work correctly (they are driven by > potential difference between the inside and the outside of the cell, > which is related to pH). This restricts the passage of oxygen but not > of glucose. So one can see a number of events which can lead to the > ceasing of oxidative respiration, leaving only glycolysis > (fermentation) as the source of energy for cancer cells. > > The formation of cancerous tissue is not a function of available > oxygen per se, that is just a corollary of the process. > So does anaerobic respiration cause cancer..., no, anaerobic > respiration is a result of the physiological conditions that cancers > cause, ie, mitochondrial damage and disfucntional membrane pores by > way of low pH. > > Regards > Ivan. > > > > > -----Original Message----- > > From: Kevin Nolan [mailto:[email protected]] > > Sent: Thursday, 4 April 2002 1:33 p.m. > > To: [email protected] > > Subject: Re: CS>Silver Compounds and > electrobiological/electromagnetic > > response > > > > > > The oft repeated claim from the alternative healing sector > > that cancer cells > > operate via a fermentation metabolism and thus are susceptible to > > oxygenation (Warburg hypothesis) is appealing and I hope true. > Stephen > > Barret of Quackwatch has justifiably received bad press here > > re CS safety. > > But that doesn't mean he gets it all wrong. On the matter of > > cancer cell > > metabolism, the following from > > http://www.quackwatch.com/01QuackeryRelatedTopics/Cancer/oxyge > > n.html is > > worth some serious pondering: > > > > "Does anaerobic metabolism cause cancer? > > In a 1961 monograph [7], Aisenberg reviewed and analyzed the > > subject of > > energy metabolism in normal and tumor tissues. He concluded that > most > > carcinogens are not respiratory poisons; most respiratory > > poisons are not > > carcinogens; oxygen neither prevents nor inhibits cancer > > growth; tumor cells > > grow optimally in tissue culture dishes in atmosphere > > containing 20% oxygen; > > tumors grow rapidly in tissues that are well supplied with > > oxygenated blood; > > absence of oxygen does not stimulate tumor growth in vitro or in > vivo; > > agents effective against cancer interfere with DNA synthesis, not > with > > aerobic metabolism; tumors do not get a significant amount of > > their energy > > from anaerobic metabolism; tumors can and do produce energy by an > > oxygen-driven metabolism of fats and carbohydrates. > > > > Since the mid 1960s, information amassed has identified > > cancer initiation, > > promotion, and progression. Alteration of genetic regulation > > through DNA > > damage, oncogene activation, and inhibitor dysregulation give rise > to > > abnormally proliferating cancer cells. There is no evidence > > of "poisoning" > > in the respiratory enzyme systems of tumor tissues. Although Warburg > > discovered some differences in metabolism between normal and > > cancer cells, > > research did not bear out what he considered to be the > > "primary cause of > > cancer," i.e., the replacement of respiration by fermentation.[7]." > > > > Worth reading the rest of that article also. Comments anyone? > > > > Kevin Nolan > > > > > -- > The silver-list is a moderated forum for discussion of colloidal silver. > > To join or quit silver-list or silver-digest send an e-mail message to: > [email protected] -or- [email protected] > with the word subscribe or unsubscribe in the SUBJECT line. > > To post, address your message to: [email protected] > Silver-list archive: http://escribe.com/health/thesilverlist/index.html > List maintainer: Mike Devour <[email protected]> >
