Dear Charles,

You said:

<<What would we have to make to be effective against anthrax?>>


Great question.  Those in labs will have to get a hold of B. anthracis that
possesses the toxic plasmid - the virulent type.  No substitutions.  Anthrax
toxins have two cell-binding component referred to as the "B, domain" and
the "A, domain".  The A, domain has the toxic, and often, the enzymatic
activity.  In this respect, anthrax is like many plant and bacterial toxins.
The A and B toxins are synthesized from different genes. They are then
secreted as non-covalently linked proteins. The B protein, which is a
protective antigen, is shared by both toxins.  This is what makes anthrax
different from ALL other plant and bacterial toxins.  This is why no
substitutions for this material will suffice.

My understanding is that all requests for this material have been flatly
refused.

Hypotheses are great.  They're a starting point.  But they cannot be
presented as fact until proven.

Regards,
Catherine




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