THANKS for the reply.  I hope someone with Interlibrary access in the
USA can get this easily.   My guess is that this is a very, very
peculiar case, but I would like very much to know the details.   Any
academics who can do this stateside? 



C Creel wrote:
> 
> Dear Jonathan,
> 
>   You said:
> 
> <<The abstract you posted is remarkable.  Could you possibly post more
> about that?  I am very curious to know how this woman ingested so much
> silver as to develop argyria, and to know why such an extensive autopsy
> was conducted.   The whole story would be tremendously useful to members
> on this list;  if you buy the MedLine report it would be a great
> service.   Few postings on this list have been as relevant as this one,
> in my opinion. >>
> 
>    The ful article is not available online but is available in the following
> libraries
> below.  Perhaps we have a list member who is local to one of these libraries
> and can pursue this.
> 
> Houston Academy of Medicine-Texas Medical Center Library
> Print Collection
> 
> Medical University of South Carolina Library
> Print Collection
> 
> Pacific Southwest Regional Medical Library Demonstration Site
> Print Collection
> 
> Pennsylvania State University College of Medicine/Milton S. Hershey Medical
> Center
> Print Collection
> 
> Stanford University - Lane Medical Library
> Print Collection
> 
> the University of Wisconsin - Madison Health Sciences Libraries
> Print Collection
> 
> University of Alabama at Birmingham Lister Hill Library of the Health
> Sciences
> Print Collection
> 
> University of Arizona Health Sciences Library
> Print Collection
> 
> University of Calgary Health Sciences Library, Canada
> Print Collection
> 
> University of Colorado Health Sciences Center/Denison Library
> Print Collection
> 
> University of Connecticut / Health Center / L.M. Stowe Library
> Print Collection
> 
> University of Florida Health Sciences Center Library
> Print Collection
> 
> University of Nebraska Medical Center Mcgoogan Library
> Print Collection
> 
> University of New Mexico Health Sciences Library
> Print Collection
> 
> University of Virginia Health Sciences Library
> Print Collection
> 
> Wake Forest University School of Medicine
> Print Collection
> 
> West Virginia University Robert C. Byrd Health Sciences Center
> Print Collection
> 
> Brain involvement in generalized argyria
> Clinical Neuropathology, 3: 1, 1984 Jan-Feb, 32-6
> >
> > Abstract
> > Cutaneous argyria was diagnosed in a 59-year-old woman. Manic depressive
> > psychosis developed at about the same or a short time thereafter. The
> > patient died 6 years later from a ruptured aortic aneurysm. At autopsy
> > silver deposits were seen in skin, mucous membranes, heart, kidney, and
> > liver. In the central nervous system the leptomeninges and choroid
> plexuses
> > contained silver granules. In addition, silver granules were visualized in
> > the walls of many intraparenchymal vessels, particularly of the basal
> > ganglia, hypothalamus, substantia nigra, and cerebellum. Progressive glial
> > changes and cellular gliosis were evident in many areas of the brain. With
> > the electron microscope the deposition of silver granules in basal
> membrane
> > structures of the choroid plexus and intracerebral vasculature was amply
> > confirmed. Furthermore, silver deposition was seen in brain parenchymal
> > cells inside bodies of apparently lysosomal nature. The silver content of
> > various brain regions was determined by absorption spectrophotometry.
> >
> > Dietl HW; Anzil AP; Mehraein P
> 
> Regards,
> Catherine
> 
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