Hello Duncan Yes, selenium is well known and taken by most Cystic Fibrosis people that I know. They also take additional antioxidants, almost all vitamins (C + all the fat solable), Calcium, Magnesium (which play a major role in many processes in the body), DHA, CoEnzymeQ10 and some antioxidant herbs and essential oils. The list of daily supplements is really long. As for the GSH - taking it orally is not.. clear. I mean there are pros and cons, something to do with the fact that when taken orally it doesn't go into the cells but stays outside (which for some reason is not good for CF). There are CF people that use it orally with success, but others are sceptical. Not many papers on that. There is a group of researchers though that investigated GSH inhalations. This is 'on the age' research, very new, not established but so far successful.
As someone pointed though all these things do not change the genetical disorder - the CFTR channel is still staffed up and so far there is no cure for that. And there are other issues - mixing and interaction between all these supplements. The more they become the more you get confused what causes what. You get bounded by all the timing and dossages ... Just recently MannaRelief started a study on the effect of their products (mainly Aloe Vera based) on CF patients. So now some take these gluconutriens as well. I'll update later today how is Kamellia going with the Colloidal Silver. Maia --- Duncan Crow <[email protected]> wrote: > Did the cystic fibrosis treatement program address > the control of > oxidative stress? I ask because there are hundreds > of articles pointing > out the culprit in lung disorders as being chronic > oxidative stress > (lipid peroxidation). This can be stopped cold with > cold-processed whey > and selenium, and an antioxidant program. > http://members.shaw.ca/duncancrow/medline_links.html > Here's just one study chosen at random so you'll see > what I mean. > > The mucus and inflammation and most of the scar > tissue is produced by > irritation from whatever sourse and propagated by > free radical damage. > Glutathione increase (requires selenium) stops all > that and also reduces > the Th2 inflammatory cell count on favour of > non-inflammatory, reduced > damage, Th1. But since all the antioxidants work > together I recommend a > program of them to my clients. > > __________________________ > Monaldi Arch Chest Dis 2002 Jun-Aug;57(3-4):173-6 > Related Articles, Links > > Role of oxidative stress in pulmonary fibrosis. > > Mastruzzo C, Crimi N, Vancheri C. > > Dipartimento di Medicina Interna e Medicina > Specialistica, Sezione di > Malattie Respiratorie, Universita di Catania, via > Passo Gravina 187, I- > 95125 Catania, Italy. > > Pulmonary fibrosis can be observed as an end state > in a number of chronic > inflammatory pulmonary diseases. Although the > mechanisms by which lung > fibrosis develops are not fully ascertained, recent > findings suggest that > oxidative stress may play an important role in the > pathogenesis of tissue > fibrosis affecting apoptosis of both structural and > inflammatory cells > and altering the cytokine microenvironment balance. > Damage and alteration > of alveolar epithelial cells is one of the hallmarks > of interstitial lung > fibrosis. Recently, it has been demonstrated that > the presence of > oxidative stress may lead to the damage, activation > and/or apoptosis of > alveolar epithelial cells either directly, through > an imbalanced > intracellular redox equilibrium, or indirectly, by > activating redox- > sensitive effector pathways, such as transcription > factors and > angiotensin converting enzyme, increasing the > conversion of > angiotensinogen into angiotensin II that can be > considered a mediator of > oxidative stress, capable of inducing apoptosis. > Furthermore, it has been > demonstrated that angiotensin II acts as a > proinflammatory cytokine and > is effective in activating fibroblasts through the > release of > transforming growth factor (TGF-beta). As well as > activation, > differentiation, proliferation and apoptosis of > fibroblasts seem related > to the oxidant/antioxidant balance, and the > maintenance of a high > intracellular level of reduced glutathione (GSH) is > considered crucial in > providing a reducing environment within the cell, > able to protect against > oxidative stress. In those conditions where > oxidants, either inhaled or > produced by inflammatory cell, increase, the ratio > between GSH and > oxidized glutathione (GSSH) may lower, influencing a > variety of cellular > redox-sensitive signaling processes such as the > activation of nuclear > factor-kB (NF-kB) and activator protein-1 (AP-1) > that lead to a > transcriptional up-regulation of a number of genes > involved in > inflammation and/or fibrogenesis, including > cytokines [interleukin (IL)- > 1,, tumor necrosis factor (TNF-alpha), IL-6] > chemokines (IL-8), adhesion > molecules (VCAM-1, ICAM-1) and growth factors > (GM-CSF). In addition, > several studies have shown that oxidative stress may > also affect the > immune response by inducing an up-regulation of > HLA-DR as well as the > expression of two costimulatory molecules such as > CD40 and CD86, > determining a persistent state of immune activation, > and affecting the > Th1/Th2 balance, modulating the T-cell effector > response towards the Th2 > phenotype. It is clear that a better understanding > of the precise > sequence of events that make the difference between > normal tissue repair > and fibrosis, including the role played by oxidative > stress, will > certainly improve our therapeutic approach to > pulmonary fibrosis. > ___________________________ > > You would be surprised.... Cystic Fibrosis people > have > > tried many things... > > One mother tried DMSO on the sputum of her Cystic > > Fibrosis son. It tickens the mucus though and she > > never tried using with on the son. Tick mucus is > > killing for them. I assume it's because their > mucus > > has a different structure. They have much more > salt in > > the sweat, etc. > > > -- > The silver-list is a moderated forum for discussion > of colloidal silver. > > Instructions for unsubscribing may be found at: > http://silverlist.org > > To post, address your message to: > [email protected] > > Silver-list archive: > http://escribe.com/health/thesilverlist/index.html > > List maintainer: Mike Devour <[email protected]> > __________________________________________________ Do you Yahoo!? Yahoo! Tax Center - File online, calculators, forms, and more http://tax.yahoo.com
