Muscle wasting is produced by autoimmune disorders and mitochondrial disorders. Both conditions are marked by the reduced production of ATP energy, and indeed a few of the autoimmunes are also part of the mitochondrial dosirders list. ATP production can be impaired by toxin
load including drugs, statins specially. > Muscle wasting? How in the world would that happen? > I think I'll forward this on to my silver list and see what they have to > say. I'll forward back any comments. MA > Here's an article I wrote for the newspaper a couple of weeks ago: _________________________________________________ Autoimmune and mitochondrial disorders linked to energy production Body Electric Duncan Crow Most of the autoimmune disorders such as diabetes, myasthenia gravis, polymyalgia, fibromyalgia, lupus, Crohns disease, arthritis, myositis, scleroderma, multiple sclerosis, muscular dystrophy and several others are characterized by low energy. The energy produced in the mitochondria of the cells, called ATP, is depleted while dealing with the toxins absorbed through exposure to a wide variety of environmental contaminants. Toxin load including infection, besides being a physical energy drain can be a trigger for an autoimmune disorder, and ATP deficiency increases the pain and other disabling symptoms. In the body, ATP: moves substances into and out of the cell; moves muscles; opens and closes channels; produces signals that stimulate hormones; detoxifies the body; teams up with sulfate to become a sulfate donor for renewal and repair. Without it, cellular function is impaired or stopped and the cell dies; this is what produces the wasting. The body needs ATP to repair and renew the same parts the deteriorate and cause pain in autoimmune disorders: chondroitin sulfate (cartilage, bone, skin, cornea, arteries); dermatan sulfate (skin, blood vessels, heart); heparan sulfate (lungs, arteries, basement membranes); heparin (lung, liver, skin, mast cell granules); keratan sulfate (cartilage, cornea, vertebral discs). About 88 lbs. of ATP per day are required for a resting human. Illness robs our bodies of ATP, and the sicker one is, the more energy one needs. Mitochondrial disorders (that involve the reduced production of ATP) are also serious and because there hasn't even been a treatment for these disorders the prognosis is always poor, ranging from progressive weakness to death. Using just one example, scleroderma is characterized by excessive deposits of collagen. Progressive systemic scleroderma, the serious type of the disease, can be fatal. In an article (published in Scleroderma Voice, 2003 #3) titled Fatigue and Weakness in Scleroderma Patients by Jane H. Park, Ph.D., from Vanderbilt University School of Medicine, Dr. Park reports, "Our studies showed that the thigh muscles of scleroderma patients at rest had an average reduction of 35% in concentrations of both ATP (adenosine triphosphate) and PCr (phosphocreatine) compared to normal muscles. These decreases were present in patients with both diffuse or limited scleroderma." Mitochondrial and autoimmune disorders are now sometimes treated with supplements that increase ATP recycling. These common supplements include coenzyme Q10, carnitine, vitamins C and K, and various components of the vitamin B complex, especially riboflavin. Lecithin, which contains the needed phosphate for ATP and PCr production, should be an asset. Ginseng and Rhea extract take the more direct approach; they actually contain ATP. Magnesium is also an important supplement because it is required by all the muscle enzymes involved in energy production. Magnesium and ATP always tightly bind together, and ATP is only active in the presence of proper concentrations of magnesium. Magnesium levels are low in the muscles of patients with either diffuse or localized disease. During the stress of exercise, magnesium deficit in the muscle is actually increased, and this is probably why wasting disorders are usually made worse rather than better when a person exercises. Salvatore DiMauro and Eric Schon, both of the Neurology Department at New York's Columbia University, reported in the January 1998 issue of The Neuroscientist, that even a little help can mean a lot in mitochondrial disorders, says DiMauro, a published neurologist. "Patients can be sick when they have 85 percent mutant mitochondria in a given tissue, but if they have 80 percent, they may be much, much better and may not show symptoms. So, if you can change the proportions even slightly, you may do the patient a lot of good." But ATP increase is useful not only to people with 'mutant mitchondria'. In an open label clinical study, people with allergies and autoimmune disorders who were given a commercial Rhea extract called ATP Boost in 1998 reported the following results of symptom remission: allergies 73 percent; pain, 77 percent; range of motion improvement, 76 percent. And 73 percent noted an increased energy level. If a tiny ATP boost from an external source can produce these results, a supplement that helps the mitochondria to function better may do much more than increase energy, it may help people with mitochondrial disorders, autoimmune diseases, and cancer. The work of Dr. William Koch and others who investigated this avenue showed that when ATP is elevated the cells become more aerobic and cancer often goes away. There's a summary article on the approach at http://tinyurl.com/5cdkv. Researcher Michel Grise really found something big when he discovered Prosoteine (TM), a protein molecule that improves mitochondrial health, an option that was previously unavailable. Prosoteine's launch promo is 1/3 off wholesale; if you buy 12 bottles you get them for the price of 9. See corporate here: http://eyicom.com/?key=comox my son's referred page :) _________________________________________________ Duncan Crow Duncan Crow (copyright waived) http://profiles.yahoo.com/duncancrow/ --- live and help live... --- -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Silver List archive: http://escribe.com/health/thesilverlist/index.html Address Off-Topic messages to: [email protected] OT Archive: http://escribe.com/health/silverofftopiclist/index.html List maintainer: Mike Devour <[email protected]>
