Thought this was interesting.
BW,
Sheila
http://www.sciencemag.org/cgi/content/abstract/304/5670/600?rbfvrToken=17e257771c0d38ccca13c1e43dce2cca932c6388
Science, Vol 304, Issue 5670, 600-602 , 23 April 2004
[DOI: 10.1126/science.1093941]
Reports
Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects
Marie E. Egan,1,2 Marilyn Pearson,1 Scott A. Weiner,1 Vanathy
Rajendran,2 Daniel Rubin,1 Judith Glöckner-Pagel,2 Susan Canny,2 Kai
Du,3 Gergely L. Lukacs,3 Michael J. Caplan2*
Cystic fibrosis is caused by mutations in the gene encoding the cystic
fibrosis transmembrane conductance regulator (CFTR). The most common
mutation, {Delta}F508, results in the production of a misfolded CFTR
protein that is retained in the endoplasmic reticulum and targeted for
degradation. Curcumin is a nontoxic Caadenosine triphosphatase pump
inhibitor that can be administered to humans safely. Oral administration
of curcumin to homozygous {Delta}F508 CFTR mice in doses comparable, on
a weight-per-weight basis, to those well tolerated by humans corrected
these animals' characteristic nasal potential difference defect. These
effects were not observed in mice homozygous for a complete knockout of
the CFTR gene. Curcumin also induced the functional appearance of
{Delta}F508 CFTR protein in the plasma membranes of transfected baby
hamster kidney cells. Thus, curcumin treatment may be able to correct
defects associated with the homozygous expression of {Delta}F508 CFTR.
1 Department of Pediatrics, Yale University School of Medicine, 333
Cedar Street, Post Office Box 208026, New Haven, CT 065208026, USA.
2 Department of Cellular and Molecular Physiology, Yale University
School of Medicine, 333 Cedar Street, Post Office Box 208026, New Haven,
CT 065208026, USA.
3 Program in Cell and Lung Biology, Hospital for Sick Children, Research
Institute, Department of Laboratory Medicine and Pathobiology,
University of Toronto, McMaster Building, Room 2032F, 555 University
Avenue, Toronto, Ontario M5G 1X8, Canada.
* To whom correspondence should be addressed. E-mail:
[email protected]
--
The Silver List is a moderated forum for discussing Colloidal Silver.
Instructions for unsubscribing are posted at: http://silverlist.org
To post, address your message to: [email protected]
Silver List archive: http://escribe.com/health/thesilverlist/index.html
Address Off-Topic messages to: [email protected]
OT Archive: http://escribe.com/health/silverofftopiclist/index.html
List maintainer: Mike Devour <[email protected]>
