DCA was discussed here about a month ago. You might check some older
messages.
Marshall
Jason wrote:
Hi All,
I know this is off topic, but I thought it might be of help to some of you.
I was sent this post by someone else and although the link is now not
working (they are selling the PDF file for $30) the university still has a
small amount of information at http://www.depmed.ualberta.ca/dca
The email reads..
--------------------
I want to let you know about what appears to me to be a major
breakthrough in research on cancer treatment. I'm not selling
anything, and I was not involved with the research, but I think it's
very exciting! I hope you won't think I've parted company with my
sanity when I tell you this.
I'm referring to work recently published by researchers at the
University of Alberta in Canada. The full paper can be found at the
following site:
http://www.depmed.ualberta.ca/dca/cancer_cell.pdf
I'm not exaggerating when I call this a major breakthrough.
Briefly, these researchers have found that a relatively simple,
non-patentable substance, namely dichloroacetate, which has been used
in the past to control lactic acidosis in children with mitochondrial
disease, is able to knock out a variety of types of cancer cells
without causing systemic problems. They have demonstrated this by
experiments in three types of human cancer cell cultures and in mice.
This substance works by blocking the enzyme pyruvate dehydrogenase
kinase, causing pyruvate to be converted to acetyl Co-A and be fed into
the Krebs cycle, instead of being reduced to lactic acid as normally
occurs in cancer cells, and thus forcing the cancer cells to change
their metabolism from glycolysis to oxidative phosphorylation, like
normal cells. As a result of this change, they are able to cause these
cells to undergo apoptosis and die, rather than being immortal as
cancer cells are. In the mice, they put this substance in their
driinkinig water, and they began to see effects on their cancer within
one week!
Because it operates on a feature that is common to all cancer cells (as
shown by Otto Warburg in 1930, for which he won the Nobel prize), this
substance promises to be a universal treatment for all types of cancers.
Because it is nonpatentable, it should be relatively inexpensive. This
also means that non-pharma money will have to be found for the phase II
and III clinical trials, and they've started a fund for that. Because
there is already a history of using this substance in humans to treat
lactic acidosis in mitochondrial disease, it is already known that the
side effects are mnimal.
I am fairly familiar with the biochemistry of the intermediary
metabolism, and I can tell you that the paper looks good to me. I
would invite comments from others on this. If this is what it looks
like to me, the ramifications are huge to society, the economy, the
cancer industry, and to all of us as individuals. I think this will
make it even more imperative that we figure out what to do for
Alzheimer's, because the average life expectancy is going to jump.
When futurists used to talk about the possibility of "a cure for
cancer" being found, I always thought they were nuts! I don't think so
anymore.
Rich Van Konynenburg, Ph.D.
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