Excerpt from:

Whose bright idea was that?

http://www.guardian.co.uk/science/2010/nov/13/inventors-idea-regret

How does it feel to invent something you later regret? Simon Hattenstone talks to the people who know

Simon Hattenstone
13 November 2010

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Ecstasy

Alexander Shulgin is known as the godfather of ecstasy. He lives with his wife Ann on a ranch in Lafayette, California, and at 85 suffers severe short-term memory loss. Ann acts as a conduit between us ­ repeating my questions to him and his answers back to me.

Ecstasy was first synthesised in 1912 by the chemical company Merck, but Shulgin resynthesised it in 1976 and was the first person to test it on a human being ­ himself. Two years later he wrote a paper with a colleague about the effect of MDMA, stating that it created "an easily controlled altered state of consciousness with emotional and sensual overtones… it didn't have the other visual and auditory imaginative things that you often get from psychedelics. It opened up a person, both to other people and inner thoughts, but didn't necessarily colour it with pretty colours and strange noises.'' He believed that with its unusual combination of effects (intoxication, disinhibition and clarity), it could be a useful drug in psychotherapy. And so it was ­ for a while. But then MDMA became ecstasy, the drug of choice for the rave generation, and in 1986 its use in the treatment of depression was banned by the US Drug Enforcement Agency. In 2000, US customs officials seized nearly 10 million pills.

Shulgin had his first psychedelic experience in 1960, and since then he estimates he has had another 4,000. (Ann says she has had only around 2,000 herself.) Some regard him as a holy man, some as a great scientist, others as a monster. The Daily Mail once ran a story headlined "Has this man killed 100 British teenagers?"

Today, Shulgin has his doubts about the drug he championed ­ not because of its efficacy, but because he believes people have abused it. "I have regrets about the way MDMA is used, because it has caused a great deal of negative publicity and been made illegal in a lot of countries. But it is still one of the great psychotherapeutic drugs."

In Britain and America, he says, people rarely talk of its therapeutic value. "You just hear about it causing young people to get into disastrous situations at raves. But MDMA is a very rich research tool and its use in the opening up the subconscious or the unconscious is very valuable."

The problem started, he says, when clubbers began popping pills with reckless abandon. And once MDMA was made illegal, there was no way to monitor the quality of the drug. "It made it impossible for people at raves to know whether they were getting MDMA. We never use the term ecstasy because it is meaningless ­ some ecstasy capsules have no MDMA in them whatsoever. So the so-called ecstasy has become a real menace." He is convinced that the outlawing of the drug has caused more problems than the drug itself.

The strange thing, Shulgin says, is that he has actually invented hundreds of psychoactive drugs, all with the same potential to open up the subconscious and unconscious, yet it is only MDMA, which he simply brought to public attention, for which he is known. "I still believe one day it will be a really important aid in psychotherapy, but MDMA has caused a lot of trouble for a lot of people in the way it was misused."

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