Sequest is not very fast. The only way to really speed up sequest is to give
it more processors, provided you are using sequest in a way that will allow
you to use the extra processors. There are many factors that affect the
speed of processing though, with the two largest being the type of digestion
and the size of the database. The number of modifications also plays a role
in the amount of time, so as you can see there isn't any one way to really
speed up sequest. Also, 10 hours isn't all that bad, try doing a no-enzyme
search on a decent sized database, that can take days on 1-2 processors.

On Fri, Jul 10, 2009 at 4:42 AM, Ali <[email protected]> wrote:

>
> Hi everyone
>
> I am doing some databse search with mzXML files generated from
> Thermo .raw files against my database.  I have a duo core 2GB RAM
> machine.  I understand that TPP does not use multi-threading but one
> mzXML file seems to take 10 hours to process!!  Is there anyway I can
> speed up this process?
>
> Regards
>
> Ali
>
> >
>

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