Zhi,

Did you use this option?
--filter "peakPicking true [1,2]"

-Matt


Zhi Sun wrote:
>
> Hi Eric,
>
> Thanks for the explanation.
>
> The mzML and mzXML files are too big to upload to spctool-discuss. I 
> uploaded the DP_Opti_Newpupi_15_2run_5May09.wiff and 
> DP_Opti_Newpupi_15_2run_5May09.wiff.scan files. The mzML and mzXML 
> files can be generated from the wiff file. I used the default options 
> to generate mzML file and --mzXML option to generate mzXML file. Two 
> mzML files was generated from the conversion,
>
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_15.mzML/ and 
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_22.mzML/. The one I 
> said needs really long loading time is
>
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_22.mzML/. The 
> loading time for
>
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_15.mzML/ is short, 
> but X!tandem report " No input spectra met the acceptance criteria".
>
> Two mzXML files also generated if I use –mzXML option. The search on 
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_22.mzXML /doesn’t 
> produce any result/,/ but the search on 
> /DP_Opti_Newpupi_15_2run_5May09-dp_2strun_newpupi_15.mzXML /got about 
> 1800 search hit.
>
> Thanks,
>
> Zhi
>
> -----Original Message-----
> From: [email protected] 
> [mailto:[email protected]] On Behalf Of 
> [email protected]
> Sent: Friday, October 02, 2009 9:33 PM
> To: [email protected]
> Cc: [email protected]
> Subject: [spctools-discuss] Re: msconvert generated mzML file
>
> And I believe there is one more clue missing from Jimmy's translation:
>
> when one of these WIFF files is converted to mzXML, then X!Tandem produces
>
> a good result. So item 1 is out, leaving just 2 or 3.
>
> Zhi, would you post a link to a zip file including a WIFF file, its mzML
>
> file, its mzXML file, and the respective search results from each file.
>
> Maybe some kind person would have a look at that zip file and see if the
>
> problem becomes apparent?
>
> Thanks,
>
> Eric
>
> > From: [email protected] [mailto:spctools-
>
> >
>
> > I'll be a translator. Zhi seems to be having issues with ABI QQQ wiff
>
> > files. They were translated to mzML using msconvert and X!Tandem
>
> > didn't like them. She mentioned ReAdW only to state that X!Tandem was
>
> > able to process some unrelated mzML files in the past.
>
> >
>
> > The problem could be:
>
> > 1) the QQQ file really has no good ms/ms spectra in it.
>
> > 2) there's a problem with the QQQ to mzML conversion.
>
> > 3) everything's fine with the data but for whatever reason X!Tandem
>
> > can't handle the particular mzML correctly.
>
> > 4) the X!Tandem spectral processing parameters are set weird.
>
> >
>
> > Even money on the first 3.
>
> >
>
> > On Fri, Oct 2, 2009 at 4:31 PM, Matthew Chambers
>
> > <[email protected]> wrote:
>
> > >
>
> > > I'm lost. You said "recently I used the msconvert to convert some QQQ
>
> > > wiff files to mzML format". Are we talking about ABI WIFF or Thermo
>
> > RAW?
>
> > >
>
> > > -Matt
>
> > >
>
> > >
>
> > > Brian Pratt wrote:
>
> > >> You probably mean mzXML rather than mzML?
>
> > >>
>
> > >> On Fri, Oct 2, 2009 at 3:55 PM, Zhi Sun <[email protected]
>
> > >> <mailto:[email protected]>> wrote:
>
> > >>
>
> > >>
>
> > >> I just mean the mzML format itself. I used ReAdw to convert RAW
>
> > >> file to mzML
>
> > >> format.
>
> > >>
>
> > >> Thanks,
>
> > >> Zhi
>
> > >>
>
> > >>
>
> > >> -----Original Message-----
>
> > >> From: [email protected]
>
> > >> <mailto:[email protected]>
>
> > >> [mailto:[email protected]
>
> > >> <mailto:[email protected]>] On Behalf Of Matthew
>
> > >> Chambers
>
> > >> Sent: Friday, October 02, 2009 3:49 PM
>
> > >> To: [email protected]
>
> > >> <mailto:[email protected]>
>
> > >> Subject: [spctools-discuss] Re: msconvert generated mzML file
>
> > >>
>
> > >>
>
> > >> Hi Zhi,
>
> > >>
>
> > >> You say it worked fine with ReAdW; do you mean mzWiff? If so,
>
> > what
>
> > >> conversion settings did you use (for both msconvert and mzwiff)?
>
> > >>
>
> > >> -Matt
>
> > >>
>
> > >>
>
> > >> Zhi Sun wrote:
>
> > >> > Hi All,
>
> > >> >
>
> > >> > Recently I used the msconvert to convert some QQQ wiff files
>
> > to mzML
>
> > >> format,
>
> > >> > and did X!tandem search using those mzML files. I ran into a
>
> > >> problem.
>
> > >> > X!tandem took really long time (2 or more hours) for loading
>
> > the
>
> > >> spectra,
>
> > >> > and them after it finally finished loading, it just reported
>
> > >> "Loaded, No
>
> > >> > input spectra met the acceptance criteria." The X!tandem runs
>
> > >> fine on
>
> > >> other
>
> > >> > mzML file. I tested on one mzML which was generated by ReAdw
>
> > before.
>
> > >> >
>
> > >> > When doing the conversion, I used default options for
>
> > msconvert.
>
> > >> Does
>
> > >> anyone
>
> > >> > of you know what could be the reason for this? If necessary, I
>
> > >> could send
>
> > >> > the wiff file and also the mzML file.
>
> > >> >
>
> > >> > Thanks,
>
> > >> > Zhi
>
> > >>
>
> > >
>
> > > >
>
> > >
>
> >
>
> >
>
>
> >

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