Hi,

I am running into trouble during the MzXML2Search export from mzXML to
mgf.

Here is what I observe:

- if you simply run "MzXML2Search -mgf file.mzXML", some scans do not
get
properly exported. I did not yet figure out the "rule" behind this
behavior, but this was particularly obvious to me since I was
expecting a set of specific 5+ or 6+ peptides.
I checked in the mzXML file and the expected precursor masses are
indeed there, and with the correct charge state properly assigned by
the mass spec instrument (QTOF). But those MS2 scans corresponding to
the precursors are clearly absent from the mgf.

- I found a message from another user in this list suggesting the
possibility to export specific charge states. So I run the command
"MzXML2Search -mgf -C2-6 file.mzXML", and while the first scans get
properly exported (you get the 2+, 3+, 4+, 5+, 6+ reports for each MS2
scan), the specific precursor I am looking for (scan=2643) gets
exported only as charge 1+, 2+, 3+, 4+?!?!?
Have somebody reported this before? Is there any option that I am not
aware of that could fix this issue?

I am happy to provide the mzXML file and specific example of set of
peptides that are not properly handled during the MzXML2Search export,
so that you may troubleshoot those by yourself.

Thanks in advance for your help with this. I really hope that will
help also other people too.

Best,

Ludovic

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