Hi everyone,

I am using the TPP tool tandem2xml for converting X!Tandem results into 
pepXML.

When using it in command line style for X!Tandem file it went through, but 
gave multiple error messages as:

WARNING: Multiple variable modifications on Q for scan 6605.

It only happened for Q (Gln, Glutamine). And only in cases, where Q is the 
N-terminal amino acid of the peptide.


The possible source for the warning message might come from the following 
fact:

- I run X!Tandem with variable modifications - deamidation on N/Q
- Furthermore, I allow N-terminal cylization (for N, Q and 
carbamidomethylated C)


in the X!Tandem parameter XML-file, the respective line looks like:

<note type="input" label="protein, quick pyrolidone">yes</note>


Could possible deamidation at Q and possilbe cylization at N-terminal Q 
interfere with each other, when converting from X!Tandem.xml output into 
pepXML-format ?


Best,

Werner

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