To search MS3 spectra in Comet, you need to set the parameter "ms_level =
3".  Typically the value of that parameter is set to "2" for MS/MS scans.

   http://comet-ms.sourceforge.net/parameters/parameters_201402/ms_level.php

Although a few of the ProteoWizard devs are here too, you might consider
sending your msconvert issue to their support list:
[email protected]

- Jimmy

On Fri, Oct 3, 2014 at 9:14 AM, Will Fondrie <[email protected]> wrote:

> Hi all,
>
> We have a RAW file that was collected using MS3 on an Orbitrap Fusion, and
> I have a couple questions about processing it.
>
> First, what is the best way to convert the RAW file to mzML, so that it
> can be searched with Comet or one of the other TPP search engines? I've
> tried using the latest version of msconvert (ProteoWizard 3.0.6736) but I
> get an error:
>
> processing file: 09222014_005.raw
> writing output file: .\09222014_005.mzML
> Error writing run 1 in "09222014_005.raw":
> [ScanFilter::parse()] error parsing "FTMS + p NSI sps d Full ms3
> 380.1937@cid35.
> 00 [email protected] [100.0000-500.0000]": bad lexical cast: source type
> value could not be interpreted as target
>
> Also, after converting the RAW file, are the any special parameters I
> would need to set in order to search it with Comet?
>
> Thank you for your help.
>
> Best,
> Will
>
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