Hi Kelly,

I noticed PeptideProphet reads in 4+, 5+ and 6+ but no 2+ or 3+ peptides. 
This seems unusual. There are also more decoy hits than non-decoys, which 
isn't what you (or PeptideProphet) want. Is this what you see in the Comet 
results?


Cheers,

Magnus


On Monday, 11 March 2019 17:48:12 UTC+1, Kelly Rios wrote:
>
> Hi all,
>
> I have been getting an error when using Peptide Prophet under the Comet 
> pipeline.
>
> The comet search itself runs fine and the pep.xml output file from the 
> comet search looks good (many spectra listed). When I go to analyze the 
> peptides in peptide prophet, I get an error that the output file cannot be 
> found (*file not found*: not created or deleted?)
>
> I have attached screenshots of what the input parameters are for the 
> peptide prophet page, and what the failed command error looks like.
>
> I have tried this now with several different input file types, but keep 
> getting this error.
>
> I have not had this error before when analyzing MS data in comet.
>
> Has anyone else seen this issue recently? I have done a quick search on 
> here myself, but none of the answers seemed to be relevant to this 
> particular issue.
>
> Please let me know, 
>
> Kelly Rios
>

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