Hi,

I have acquired the DDA and DIA data on various tissues, and trying to 
build a spectral library by combining the DDA results of all tissues, that 
can be used further for the DIA data analysis. I am trying two approaches- 
one assay library generation with SpectraST and other using skyline to 
build the library. Now, I confused, how should I proceed.

Should I combine the peptideprophet results of various tissues by using 
iProphet? 
Or, create assay libraries for each tissue separately using the SpectraST 
and then import them separately in a common Skyline document?

I would be very grateful for your help.

Thanks in advance. 

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