spyder is focused on editing, running and interacting with python code 
(*.py).
Although you can edit cython (which looks similar but is not python) code, 
*.pyx, in the editor, you should read the cython tutorials on how to 
compile these into python extensions and wrappers 
e.g., 
http://docs.cython.org/src/tutorial/cython_tutorial.html#cython-hello-world

On Tuesday, March 31, 2015 at 10:09:06 AM UTC-4, Barrett Brister wrote:
>
> I am running Spyder 2.3.1, and I am attempting to run a Helloworld.pyx 
> file to give Cython a shot. But the "Run" command--the button and F5--does 
> not work. I know that what I'm really trying to do is get this ported into 
> a .c file, but how? How do I get .pyx files up and running?
>

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