Since no one replies, I'll put some of my thoughts. I don't use Xen but I use 
VMware ESX, so the idea should be similar.

1. I usually create one virtual disk for OS, data on another virtual disk or 
san/nfs. Alignment for OS doesn't matter too much, but for data,it does. I use 
64k alignment for data disk, but as long as it's multiplier of 32k it should be 
ok.

2. You can add more disks to zpool later.

3. You can use multipathing or nic teaming. No idea about IB with comstar, I 
use 4Gb FC (qlogic), works extremely well.

4. No idea about status of dedup. However, dedup takes a lot of system 
resources so you SAN server needs to be very powerful. I have it on our netapp 
and datadomain in production. Depending on your data, we see quite big gain in 
space. With ZFS, you can turn on compression.

However, dedup makes it very hard to predict space usage. When we backup 
deduped volumes, data has to be de-deduped and transfer to backup server. In 
one datastore, we see volume usage about 150G but during backup, it transfers 
over 700G data.
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