I had the same experience. I'm running Windows XP SP3 on an Intel 1.4Ghz 
Tualatin-S system. The 2.46 installed but when I tried to launch 2.46 I got the 
same error message.

I uninstalled 2.46 and re-installed 2.40. Back to normal, no 
email/contacts/bookmarks lost. 

Not looking forward to the next new release. 
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