Variance in chemical exposure tolerance _http://findarticles.com/p/articles/mi_m0ISW/is_/ai_n15341116_ (http://findarticles.com/p/articles/mi_m0ISW/is_/ai_n15341116) Townsend Letter for Doctors and Patients, August-Sept, 2005 by Don Richard Paladin In 2002 I wrote an article trying to help explain why one person may have a low tolerance for a chemical and others may not. (1) Very recent research from Canada may demonstrate a relationship between deficiencies of enzymes and chemical intolerance. (2) I would highly recommend that The American Academy of Family Physicians, The American Medical Association, and others review their position on Environmental Intolerance (Multiple Chemical Sensitivity). There is much literature sponsored by advocates for industry that attempts to minimize the consequences of synthetic toxic chemicals by suggesting that those who report symptoms from these chemicals have psychosomatic disorders. (3,4) There are likely relationships between environmental triggers and psychological as well as other symptoms. Symptoms, however, are not causes. Dr. Robert Haley has reported a relationship between Gulf War Syndrome and a deficiency of the enzyme serum paraoxonase (Pon-Q) that detoxifies organophosphates. He has concluded that a deficiency of this enzyme can explain why one soldier may tolerate a higher dose of an organophosphate exposure and another may be damaged and become ill. (5) A recent report in the New York Times explains, "Citing new scientific research on the effects of exposure to low levels of neurotoxins, the Research Advisory Committee on Gulf War Veterans' Illnesses concludes in its draft report that "a substantial proportion of Gulf War veterans are ill with multisymptom conditions not explained by wartime stress or psychiatric illness. A growing body of research suggests that many veterans' symptoms have a neurological cause and that there is a "probable link" to exposure to neurotoxins." (6) Recent research by Ella H. Sklan et al. may help explain the Panic Attack and anxiety connection to exposures to stimuli that may be toxic (like pesticides). "Serum AChE and PON enzyme activities were both found to be affected by demographic parameters, and showed inverse, reciprocal associations with anxiety measures." (7) If one has a much lower level than normal of the enzymes involved in detoxification of any given stimuli (Pon-Q and organophosphates are the example I am using), then one will have a lower tolerance to the stimuli. It is interesting that a lower level of PON-Q and AChE may also be implicated in the precipitation of anxiety. This suggests the lower level of enzymes and other biochemicals may be responsible for symptoms of anxiety and panic disorders. It is time we move away from a psychological explanation of the cause of chemical intolerance and try to understand the rudimentary biochemistry behind the illness. Not only will this information help those with antibody mediated allergies but also greatly help those with intolerances to environmental stimuli. Since MCS (Chemical Intolerance, Environmental Intolerance) is not an antibody mediated allergy, I believe allergy specialists and others should acknowledge they do not understand the mechanism of the disorder and quit trying to discount it with a "psychogenic" canard. I am sure that anyone with any knowledge of medical history knows that both antibody mediated allergies and asthma were once considered to be psychosomatic. There is a great deal we don't understand. A little humility by the allopathic medical community would go a long way. There is now research from Japan in which they conclude: "MCS patients do not have either somatic or psychologic symptoms under chemical-free conditions, and symptoms may be provoked only when exposed to chemicals." (8) Don Richard Paladin Bellingham, Washington USA [EMAIL PROTECTED] (mailto:[EMAIL PROTECTED]) References 1. Understanding Chemical Intolerance, an investigation by Don Richard Paladin, _http://wsmcsn.s5.com/understandci.htm_ (http://wsmcsn.s5.com/understandci.htm) 2. Gail McKeown-Eyssen, Cornelia Baines, David E. C. Cole, Nicole Riley, Rachel F. Tyndale, Casecontrol study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR, International Journal of Epidemiology, doi:10.1093/ije/dyh251, _http://ije.oupjournals.org/cgi/content/abstract/dyh251v1_ (http://ije.oupjournals.org/cgi/content/abstract/dyh251v1) 3. Multiple Chemical Sensitivity Under Siege by Ann MacCampbell, MD, Townsend Letter for Doctors & Patients, January 2001, #210, p. 20-27 at _http://www.tldp.com/issue/210/mcsundersi.htm_ (http://www.tldp.com/issue/210/mcsundersi.htm) in which she writes. "When confronted by the harm they have caused, corporations typically blame the victims, deny the problem, and try to avoid responsibility for the harm caused. The corporate response to MCS has been no different." 4. The Chemical Manufacturers Association's Environmental Illness Briefing Paper, 1990 in which they state: "Because it has the potential to impact many segments of society, many groups have an interest in placing environmental Illness in its proper perspective.... Because environmental illness is a health issue, the only people who can legitimize it are physicians, and they have not. Should environmental illness arise as an issue, a coalition with the state medical association is absolutely necessary." _http://users.lmi.net/~wilworks/books/cmaeibri.htm_ (http://users.lmi.net/~wilworks/books/cmaeibri.htm) 5. The University of Texas Southwestern Medical Center at Dallas, UT Southwestern researcher finds genetic cause for Gulf War syndrome, _http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=144_ (http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=144) 6. Shane, Scott, Chemicals Sickened '91 Gulf War Veterans, Latest Study Finds, The New York Times, October 15, 2004 _http://www.nytimes.com/2004/10/15/politics/15gulf.html?oref=login&oref=login&oref=login&ei=5094&en=0f74f8004623b4bf&; hp=&ex=1097812800&partner_ (http://www.nytimes.com/2004/10/15/politics/15gulf.html?oref=login&oref=login&oref=login&ei=5094&en=0f74f8004623b4bf&hp=&ex=10978 12800&partner) 7. Ella H. Sklan, Alexander Lowenthal, Mira Korner, Ya'acov Ritov, Daniel M. Landers, Tuomo Rankinen, Claude Bouchard, Arthur S. Leon, Treva Rice, D.C. Rao, Jack H. Wilmore, James S. Skinner and Hermona Soreq, Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics Study Biochemistry, April 13, 2004 | vol. 101 | no. 15 | 5512-5517. _http://www.pnas.org/cgi/content_ (http://www.pnas.org/cgi/content) 8. Saito M, Kumano H, Yoshiuchi K, Kokubo N, Ohashi K, Yamamoto Y, Shinohara N, Yanagisawa Y, Sakabe K, Miyata M, Ishikawa S, Kuboki T.; Psychosom Med. 2005 Mar-Apr;67(2):318-25, _http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15784800_ (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15784800) COPYRIGHT 2005 The Townsend Letter Group COPYRIGHT 2005 Gale Group Don Richard Paladin "Variance in chemical exposure tolerance". Townsend Letter for Doctors and Patients. 27 Sep. 2008. _http://findarticles.com/p/articles/mi_m0ISW/is_265-266/ai_n15341116_ (http://findarticles.com/p/articles/mi_m0ISW/is_265-266/ai_n15341116) (http://www.papercut.biz/emailStripper.htm)
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