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http://www.technologyreview.com/TR/wtr_16696,323,p1.html

Thursday, April 13, 2006
Singapore Becoming a Biotech Mecca

The island nation is stealing away scientists from around the world for its
well-equipped and well-funded labs.

By Associated Press

CHICAGO (AP) -- Singapore's siren song is growing increasingly more
irresistible for scientists, especially stem cell researchers who feel
stifled by the U.S. government's restrictions on their field.

Two prominent California scientists are the latest to defect to the Asian
city-state, announcing earlier this month that they, too, had fallen for its
glittering acres of new laboratories outfitted with the latest gizmos.

They weren't the first defections, and Singapore officials at the
Biotechnology Organization's annual convention in Chicago this week promise
they won't be the last.

Other Asian countries, including Japan, South Korea and even China, are also
here touting their burgeoning biotechnology spending to the 20,000
scientists and biotechnology executives attending the conference.

But what sets Singapore apart is the sheer size of its effort to become the
''Boston of the east'' -- along with its promise to limit government
meddling.

The 250-square-mile island nation known to some as the place that canes
miscreants and has issues with chewing gum has already spent $4 billion on
biotechnology and has committed another $8 billion through 2010 in a bid to
give the United States a run for biomedical supremacy.

''I am absolutely amazed at what they have. It's just knock-dead gorgeous,''
said Dr. Judith Swain, a University of California, San Diego, heart
researcher who will decamp to Singapore in September to run the country's
new Singapore Institute for Clinical Sciences at a state-funded research
wonderland called Biopolis.

Swain's husband, Dr. Edward Holmes, who is dean of the UCSD medical school
and a ranking official with California's stem cell agency, is also going to
Singapore to work as a government researcher.

The two join Alan Colman, the British researcher who played a pivotal role
in cloning Dolly the sheep; another husband-and-wife team, National
Institutes of Health researchers Neal Copeland and Nancy Jenkins; and an
increasing number of stem cell scientists.

All have been lured by lucrative pay, state-of-the art labs and -- the
clincher -- nearly unlimited government support.

''They have recruited some extraordinary people,'' Holmes said.

In all, the country has managed to recruit about 50 senior scientists -- far
short of what it needs, but a start for a tiny country of 4.5 million people
off the tip of Malaysia.

Another 1,800 younger scientists from all corners of the world staff the
Biopolis laboratories, which were built with $290 million in government
funding and another $400 million in private investment by the two dozen
biotechnology companies based there. Biopolis opened in 2003 and contains
seven buildings spread over 10 acres and connected by sky bridges.

Copeland said he's leaving for Singapore because of its unfettered support
of human embryonic stem cell research. In the United States, federal funding
has been severely restricted by President Bush because of moral opposition
to the work, which requires destroying days-old embryos. Copeland and
Jenkins spurned an attractive offer to join Stanford University's stem cell
department in favor of Singapore.



At the center of Singapore's emergence is Philip Yeo, the government
official in charge of recruiting scientific talent as chairman of his
country's version of the NIH, called the Agency for Science, Technology and
Research.

Showing off a model of the Biopolis complex at the Singapore booth at the
biotech convention, Yeo slyly grins and mentions that he had just finished
breakfast with yet another prospective recruit.

''I am offering them academic freedom,'' Yeo said, adding that recruits
typically get sizable five-year government grants with few strings attached.
''They don't need to spend their time writing grant applications. We are
much more efficient.''

Freedom from paperwork is one thing, but some question whether some of
Singapore's harsh social policies, which include punishing political
dissent, can attract and retain enough top scientists.

Last year, Britain's Warwick University dropped plans to open a Singapore
campus after its faculty overwhelmingly protested that the country's
restrictions on free speech could cause trouble for outspoken students and
professors.

U.S. scientists working with Singapore say they haven't encountered
recruitment barriers or other problems because of the country's sometime
strict laws.

''I would say just the opposite,'' said Dr. Victor Dzau, dean of Duke
University's medical school, which is starting a Singapore program next
year. ''In fact, I would say we have an embarrassment of riches. People are
actually seeing this as a great opportunity.''

An agitated Yeo added that foreign scientists have little to worry about as
long they don't mix in Singapore's internal politics and foreign policy.

''I don't see it as an issue. It's silly,'' he said. ''We are a small
country surrounded by larger ones and everyone needs to be sensitive to
that.''


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