AGEING REVERSAL
As recd from a friend:
Q at Altos labs, told Sky News. "Rather, there are processes that can be
manipulated, you can tweak it. In certain ways, I interpret aging as a
software error."
There is a protein called apelin that circulates in the blood, and
we saw that middle-aged people with higher levels of apelin in their blood
were living longer, with better muscle function and better cognitive
function as they age," Fortney said, according to Express.
"So, we gave this drug to really old mice and we showed that it could
improve their muscle function. It helped them run faster in their wheels,
it increased their muscle size, it improved their grip strength," the Bio
Age Labs CEO added.
All that's left is to mimic the same results in older humans, and a trial
is underway to this end.
"We are elated that we can use this approach across the lifespan to slow
down aging in normal animals. The technique is both safe and effective in
mice," Juan Carlos, professor at Salk's Gene Expression Laboratory, said.
The traction anti-aging is receiving is only going to grow. According to a
report by P&S Intelligence, the global anti-aging market is expected to see
an astronomical rise from the current $191.5 billion to a mind-blowing
$421.4 billion by 2030, as per Express.
Xxxxxxxxxxxxxxxxxx
KR Marketing? Yes Indeed. The oldest according to science is 122 and
Vedas fixed it as 120. Who is better at understanding and getting
convinced? How much profit diabetic, age etc can be made is the research?
2 There are books such as “AGEING GRACEFULLY “etc. But the research
says that by spending money per day, one can live longer but did not
counter that mice whether dead AS OF TODAY OR NOT? Death is inevitable. And
the Vedas say Dharmic living had the highest growth and longest years of
living competing with the time. But it was fixed as shatamanam Bhavati or
120 years of span of life with the 9 planets dividing the eras by the
number of years. 2 Cycles of years. But all depends on our Karma
accumulated in the bag when we were born.
3 Pashyema sharada shatam (2)Jivema sharada shatam (1)
Vudhyema sharada shatam (3)Rohema sharada shatam (4)
Pushema sharada shatam (5)Bhavema sharada shatam (6)
Bhuyema sharada shatam (7)Bhuyasi sharada shatam (7).
For a hundred autumns, may we see (1), For a hundred autumns may we live
(2), For a hundred autumns may we know (3), For a hundred autumns may we
rise (4), For a hundred autumns may we thrive (5), For a hundred autumns
may we be (6), For a hundred autumns may we become (7), *and even more than
a hundred autumns.* (8)
KR The existence unto or more than 100 years is with the fitness, LIVE,
KNOW, RISE, THRIVE, BE AND BECOME; MAY BE BEYOND 100 YEARS, 120 OR > THAT.
Active life is mentioned.
*sahasra Ayuh* sukritah chareyam || ------ *For all thousand years of our
life*, may we be doing good work. (Atharva Veda 17.1.27) siranjeevi is
beyond all.
Manu Smriti mantras are not "unbelievable" by any means.
ArogAh sarvasiddhArthash Charurvarshashat ayushah |
Krite tretA dishu hoshAm Ayur hrashati pAdashah ||
(Men are) free from disease, accomplish all their aims, and live four
hundred years in the Krita age, but in the Treta and (in each of) the
succeeding (ages) their life is lessened by one quarter.
The state of living of elderly in the Vedic age and at present Global age
is distinctly making differences. In present context, elderly face various
problems such as:
a. physical fitness and health problems,
b. financial problems,
c. psychological problems and
d. problems of interaction in a social or family setting Psychosocial and
environmental problems include feeling of neglect, loss of importance in
the family, loneliness and feeling of unwantedness in family as well as
society, feeling of inadequacy and obsolescence of skills, education, and
expertise.These aspects are somewhat interdependence in nature; each aspect
may affect the quality and quantity of the problems in other categories.
The reasons for this critical living of elderly are associated with
globalization and Global cultural bound syndrome. This gives birth to the
consumer class for which people change their lifestyle and life choices
irrespective of their age and gender. Elderly population is not beyond the
tract of consumerism. At their post retirement, they also adopt a high
consumerist lifestyle which results in soaring rates of heart diseases and
diabetics, surging health costs and a lower quality of day-to-day life.
Their philosophy of happiness is like a want-created
consumption. Essentiality of their living suffers from mental illness so
that they do not like to follow age-related restrictions or limitations for
their painless survival. They prefer to take highly processed food which is
being wrapped with loneliness, workless time passed in their leisure and
truncated network of social relationships. There is no alternative
engagement in their post retirement beyond watching television and such
entertainment.
Consequently, major developmental crises associated with aging include:
dependence, isolation, illness, loss, retirement, and death. The overall
situation has changed the living status of the elderly in India.
Samples researched data: “We find that 70% of the informants were alone
living with their conjugal partners with the assistance of domestic help
and their off-springs were living separately. There were two reasons behind
this problem. Firstly, 58% of their off-springs had settled themselves
outside the city and the off-springs of rest informants lived separately
within the same city because either their off-spring did not take
responsibility of looking after or they were unable to adjust with their
family members. They had very infrequent contact with their off-spring and
relatives. On the other hand, 30% of the informants lived with their
off-spring with their conjugal partner.
In this study, the informants were economically self-dependent. Either they
had financial plans for their retired lives or they were pensioners. Their
conjugal partners were also under their financial plan. They were not
burdened by their off-springs. But they used to extend their help to their
off-spring during any crisis or emergency. From food, clothing, health care
and others any liability and financial responsibility they managed
themselves.
The Table 1 Referred that 28% male informants were public servants and
among them 6% had below matriculation level education while 22% elderly had
matriculation and above education. Secondly, the pattern of employment
showed that 21% male informants were employees in private sectors where 3%
of them were more than the below matriculate informants. Out of 20%
business men, 12% of them were matriculate and above educational
experience. Thereafter, we find that 8% were in other jobs and among them
6% informants had matriculation and above education. Among the female
elderly population, in this study, 3, out of 25 were public servants and
they had matriculation and above education. Rest of them was homemaker.
*Occupation*
*Education*
*Total*
*(n, %)*
*Below Matriculation*
*Matriculation and above*
M(n, %)
*F(n, %)*
*M(n, %)*
*F(n, %)*
Service in public sectors
6(6)
-
22(22)
3(3)
31(31)
Private sectors’ employee
9(9)
-
12(12)
-
21(21)
Business
8(8)
-
12(12)
-
20(20)
Homemaker
-
6(6)
-
16(16)
22(22)
Others
2(2)
-
6(6)
-
8(8)
Total
25(25)
6(6)
50(50)
19(19)
100(100)
*Table 1* Education and occupation of the informant’s elderly.
*Health status of the elderly*
The table shows that the majority of the studied elderly were in health
problems. Among them 85% 9ncluding 21% female elderly were suffering from
lifestyle diseases i.e. heart diseases, hypertension, diabetes and high
blood pressure, etc. Of them 78% (including 20% female) elderly had
physical mobility problem and they were mentally ill.
*Health Problems*
*Male*
*(n, %)*
*Female*
*(n, %)*
*Total*
*(n, %)*
Lifestyle related diseases i.e. heart disease, hypertension, diabetes, high
blood pressure
64(64)
21(21)
85(85)
Problem of physical mobility and mental illness
58(58)
20(20)
78(78)
No such problems
10(10)
5(5)
15(15)
*Table 2* Health problems of informants.
They lived with the main support of medical observation and medical therapy
and they were facing the problems of isolation and negligence from their
immediate family. Their alternative engagement is limited to self-care and
managing unhealthy living (consuming food and watching television).
On the other hand, 15 elderly (10 male + 5 female) had no such problems
like the above population. They had little problems fully related to their
age. They did not mind for this and they did not believe in taking help of
medical therapy for this. They usually spent their whole lives doing
different activities with spiritual practices. They preferred to detach
from any emotional affiliation and they believed in simple living and
renunciation was the key tool of their happiness.
Happiness/un-happiness is a mental state and there is no parameter of
measurement of it. Only it depends on the individual's need and demands and
its fulfillment. The level of satisfaction is determined by it. We see when
an individual is not able to access his/her demand of life for enjoyment,
he/she feels unhappy compared to other fellow members. Materials need and
demand in consumerism do not bring happiness and peace in mind and life. It
only increases one’s greed and mental anxiety.
The studies of individual elderly revealed their unhappiness for
non-fulfilment of their demand at their end part of life. This elderly
population adopted the life of enjoyment and they were trying to compete
younger. They did not follow the rules of renunciation.
*Conclusion*
The forenoon phase of life is embarked with enjoyment and there are some
duties and responsibilities to be performed in this phase. It influences
materials need and demand in changing scenarios. But at the afternoon phase
of life, there is a need of renunciation and detachment emotionally and
functionally. Simple living style with practice of spirituality helps to
lead a peaceful happy life. There is no place of greed in this phase. It is
the practice of Vanaprastha. In this study, we find that the majority of
the elderly were submerged with greed and they were seeking attachment to
their off-spring. Highly consumerised life and want created consumption
influenced their unhappy life style. It was the prime cause of their
painful living.
Further, we find that a little portion of them was practicing the path of
Vanaprastha with simple living and spiritual practice. They were preparing
themselves to accept death happily. So, there is need for spiritual
practice and teaching in the line of Vanaprastha to renounce and detach
from the practice at the forenoon phase.
Vedic scriptures paved the way of life; but we had our own
definitions; and so age factor under the research, whether west or east,
has few factors, to stretch on limited conditions. Mice will die. And
Marketing will survive. KR IRS 241122
On Thu, 24 Nov 2022 at 10:38, Rangarajan T.N.C. <[email protected]>
wrote:
> medicaldaily.com
> <https://www.medicaldaily.com/can-aging-be-reversed-scientists-are-verge-turning-it-reality-467475?ref=thefuturist>
> Can Aging Be Reversed? Scientists Are On The Verge Of Turning It Into A
> Reality
> Nov 18, 2022 04:42 AM By Urja Kalyani
> 3–4 minutes
> ------------------------------
>
> Thanks to extensive research in the anti-aging field and funding by
> billionaires, a number of scientific startups are on the cusp of delivering
> age-reversal solutions.
>
> The newest entrant in the biotech world is Altos Labs. Launched earlier
> this year, it boasts four Nobel prize winners as its board members. With a
> funding of $3bn, Altos Labs has some high-profile investors
> like Amazon founder Jeff Bezos.
>
> "Ageing is not the same as rust accumulating on a car, it's not just
> breakdown," Prof Horvath, one of the reputed academics at Altos labs,
> told SkyNews. "Rather, there are processes that can be manipulated, you can
> tweak it. In certain ways, I interpret aging as a software error."
>
> Unbelievably, the oldest human to have ever lived was Jeanne Calment, who
> died aged 122 in France in 1997.
>
> "There are no hard limits imposed by biology or by physics that says that
> we can't live better longer," Kristen Fortney, CEO of San Francisco-based
> BioAge Labs, told the outlet. Focused on discerning the markers of aging,
> BioAge Labs is using large amounts of biobank blood and tissue samples to
> do so.
>
> The company has already found a drug target that slows aging-linked muscle
> loss in mice.
>
> "There is a protein called apelin that circulates in the blood, and we saw
> that middle-aged people with higher levels of apelin in their blood were
> living longer, with better muscle function and better cognitive function as
> they age," Fortney said, according to Express.
>
> "So, we gave this drug to really old mice and we showed that it could
> improve their muscle function. It helped them run faster in their wheels,
> it increased their muscle size, it improved their grip strength," the
> BioAge Labs CEO added.
>
> All that's left is to mimic the same results in older humans, and a trial
> is underway to this end.
>
> Another participant against the race of time is Salk Institute for
> Biological Studies, a scientific research institute in California.
> Scientists at the institute reversed the aging in middle-aged and elderly
> mice through their experiments and a method called cell rejuvenation
> therapy. The process involved the use of reprogramming molecules that
> turned back the cells to a younger state.
>
> "We are elated that we can use this approach across the lifespan to slow
> down aging in normal animals. The technique is both safe and effective in
> mice," Juan Carlos, professor at Salk's Gene Expression Laboratory, said.
>
> The traction anti-aging is receiving is only going to grow. According to a
> report by P&S Intelligence, the global anti-aging market is expected to see
> an astronomical rise from the current $191.5 billion to a mind-blowing
> $421.4 billion by 2030, as per Express.
>
>
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