In the novels of Anne Rice, Those Who Must Be Kept are the progenitors of all 
vampires who are also regarded as the King and Queen of the Vampires.
Originally King Enkil and Queen Akasha of Kemet (now Egypt) circa 5,000 BC, 
they became the first vampires when an evil spirit named Amel was able to enter 
the body of Akasha through a wound and fuse with her flesh. Akasha then turned 
Enkil into a vampire by drawing out nearly all of his blood and then allowing 
him to drink nearly all of hers. (See: The Queen of the Damned)
The term "Those Who Must Be Kept" was coined by the vampire Marius referring to 
the fact that what befalls Akasha and Enkil also befalls all vampires; if they 
are injured, so are their children, if they die, so do all vampires. An example 
of this is explained in the story of Marius' life: The current caretaker of the 
two sought to be free of them, and placed them in the sun. The two lived, but 
weaker vampires were destroyed by spontaneous combustion.
Long before Marius came into conservatorship of Those Who Must Be Kept, they 
were nearly completely inanimate, seated seemingly unconscious for centuries 
without moving.
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I personaly Hate The Queen cause she kidnapped Lestat just when Louis came back 
to him.MotN

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