I ran into the same problem, but fixed it. I use Chrome on Linux and Mac and my (new and empty) TW5 just refused to save to TiddlySpot, downloading instead.
*The fix:* I've installed TiddlyDesktop and launched my TW5 file in it (just *once*). Filled out the form at Control Panel \ Saving \ TiddlySpot Saver and saved my wiki (just *once*). It have uploaded! >From there on saving that uploaded TW worked fine from anywhere -- You received this message because you are subscribed to the Google Groups "TiddlyWiki" group. To unsubscribe from this group and stop receiving emails from it, send an email to tiddlywiki+unsubscr...@googlegroups.com. To post to this group, send email to tiddlywiki@googlegroups.com. Visit this group at https://groups.google.com/group/tiddlywiki. To view this discussion on the web visit https://groups.google.com/d/msgid/tiddlywiki/a1fc619b-4f72-44ea-983f-baf8c92a707e%40googlegroups.com. For more options, visit https://groups.google.com/d/optout.