On Wed, 9 Jan 2002, John W. Kulig wrote, responding to a news
item that Okinawans live long even if they don't prosper:
>

> Okinawa was cited in the article by Pinel, Assanand & Lehman
> (2000) Hunger, Eating and Ill Health. American Psychologist.
> 55(10) 1105-1116. In this article they cite the fact that
> people on Okinawa eat 20 to 38% less calories than
> recommended by Japanese Health Authorities. i.e. they not
> only fail to overeat - they eat less than you are supposed
> to.

Perhaps this is mentioned in the Pinel article cited, but it's
well established that dietary restriction is the only
known way of prolonging life in a variety of species. As I
couldn't remember the source of this, I did a PubMed search, and
came up with this recent confirmatory review:

Van Remmen H, Guo Z, Richardson A.

Novartis Found Symp 2001;235:221-30; discussion 230-3
The anti-ageing action of dietary restriction.

Over 60 years ago, McCay's laboratory showed that dietary or
calorie-restriction dramatically increased the lifespan of rats.
Since then, numerous laboratories with a variety of strains of
rats and mice have confirmed this initial observation and have
shown that reducing calorie intake (without malnutrition)
significantly increases both the mean and maximum survival of
rodents. Currently, dietary restriction is the only experimental
manipulation that has been shown to retard ageing of mammals.
Although mechanism whereby dietary restriction retards ageing is
currently unknown, much of the emerging data suggest that the
calorie-restricted rodents live longer and age more slowly
because they are more resistant to stress and have an enhanced
ability to protect cells against damaging agents.


For those who'd like to try this at home, I also recall that the
degree of dietary restriction to achieve this was _severe_. This
means that even if it doesn't actually make you live longer, it
will sure feel like it. So far, I'm unaware of anyone who has
attempted to demonstrate this in humans. Long life seems an
insufficient reward for prolonged starvation.

-Stephen
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