The Science Daily website reports on some published research
that suggests that there may be a genetic basis for placebo
responses which would also explain who some people show
a strong placebo response and others not so much. See:

http://www.sciencedaily.com/releases/2009/07/090720191147.htm

Quoting from the article:

|Placebos are thought to act by stimulating the brain's central 
|reward pathways by releasing a class of neurotransmitters 
|called monoamines, specifically dopamine and norepinephrine. 
|These are the brain chemicals that make us "feel good." Because 
|the chemical signaling done by monoamines is under strong 
|genetic control, the scientists reasoned that common genetic 
|variations between individuals - called genetic polymorphisms - 
|could influence the placebo response.

And:

|Leuchter noted that this is not the sole explanation for a response 
|to a placebo, which is likely to be caused by many factors, both 
|biological and psychosocial. "But the data suggests that individual 
|differences in response to placebo are significantly influenced by 
|individual genotypes," he said.

NOTE:  potential conflicts of interests are listed at the end of
the article.

-Mike Palij
New York University
[email protected]




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